Pacemaker DDD Clinical Trial
Official title:
LEFT Bundle Pacing vs Standard Right Ventricular Pacing for Heart Failure
High burden right ventricular (RV) pacing has been shown to increase cardiovascular mortality, incidence of heart failure (HF), worsen left ventricular (LV) function and accelerate the development of atrial fibrillation (AF). High percentage ventricular pacing and wider paced QRS in the setting of normal baseline LV ejection fractions have consistently been shown to be independent risk factors for pacing-induced cardiomyopathy. Left bundle branch pacing (LBBP) has emerged as a potential alternative pacing mechanism that may avoid LV dyssynchrony and pacing-induced LV dysfunction by mimicking native electrical conduction.
We hypothesize that in patients with high degree AV block with anticipated ventricular pacing >90%, and an EF >35% patients undergoing LBBP will demonstrate a significantly lower number of the primary composite endpoint of cardiovascular death, heart failure events, and change in LVESVi as compared to standard RV pacing. Echos will be performed at baseline, 12, 24, and 36 months. NTproBNPs are performed at baseline and follow-up. There will be a core echo lab, and blinded adjudication of ECGs and events. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04323670 -
Master Study Investigating the Guiding Catheter Selectra 3D
|
N/A | |
| Recruiting |
NCT02931760 -
Placement Of Cardiac PacemaKer Trial (POCKET)-RCT
|
N/A | |
| Completed |
NCT03727542 -
Influence of Short AV Delay Permanent Pacing on Matrix Metalloproteinase Levels
|
N/A | |
| Not yet recruiting |
NCT06045143 -
Right Ventricular Septal Versus Apical Pacing: Echocardiographic Study
|
||
| Completed |
NCT04163965 -
Data Collection for Pacemaker Recognition Through Capacitive ECG
|
N/A | |
| Not yet recruiting |
NCT06377046 -
Accelerated Pacing in Patients Undergoing Pace-and-ablate Strategy With LBBAP: a Randomized Controlled Pilot Trial
|
N/A | |
| Completed |
NCT06068699 -
Postcards to Improve Remote Monitoring Adherence Among Veterans
|
N/A | |
| Completed |
NCT04269733 -
Risk of Pacing-induced Cardiomyopathy
|
||
| Recruiting |
NCT05868616 -
Non-Invasive Method for Evaluation of Cardiac Resynchronization Therapy
|
||
| Recruiting |
NCT06371846 -
Comparative Study of the Surface Electrocardiogram Signals During the Implantation of Conduction System Pacing Devices
|
||
| Recruiting |
NCT03357926 -
Prospective Database for Prediction of Atrial Fibrillation in Pacemaker and ICD Patients
|
||
| Recruiting |
NCT05884359 -
Left Bundle Branch Area Mapping for Conduction System Pacing
|
||
| Completed |
NCT04372654 -
Pilot Study Evaluating the Safety of Electroducer Sleeve Medical Device for Temporary Cardiac Stimulation During Percutaneous Cardiovascular Interventions, in All Kind of Patients
|
N/A | |
| Not yet recruiting |
NCT05695534 -
Use of VR in Patients' Education Prior to Implantation of PPM
|
N/A | |
| Completed |
NCT04067024 -
Evaluation of the Effectiveness of the Supraclavicular Block Associated With a Pecs Blocks I to Ensure Analgesia When Placing a Pacemaker
|
N/A | |
| Recruiting |
NCT06318130 -
Comparison of Pacing Lead Design on Left Bundle Branch Pacing Outcomes
|
N/A | |
| Recruiting |
NCT04416958 -
Pacing to Maintain Physiologic Ventricular Activation
|
||
| Completed |
NCT05222672 -
Electrical and Mechanical Activation in PAcing The His Bundle Conduction sYstem
|
||
| Enrolling by invitation |
NCT04383392 -
QoL Between CIEDs With and Without Rate Adaptive Pacing
|
N/A | |
| Completed |
NCT04957771 -
Effect of Standardized Exercise on Cardiopulmonary Function in Patients With Permanent Pacemaker Implantation
|
N/A |