Oxytocin Clinical Trial
Official title:
Influence of Oxytocin on Neurophysiological Responses to Direct and Averted Gaze
Verified date | July 2019 |
Source | KU Leuven |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Previous research has indicated that direct eye gaze compared to averted gaze, elicits a
higher skin conductance response (SCR), and a more pronounced left frontal cortex activity
than right frontal cortex activity (resulting in positive asymmetry scores). On a behavioral
level, participants tend to look shorter at live faces with a direct gaze as compared to
averted gaze (Akechi et al., 2013). Further, subjective evaluations showed that a direct gaze
is rated more arousing and less pleasant than an averted gaze (Akechi et al., 2013; Hietanen,
Leppänen, Peltola, Linna-aho, & Ruuhiala, 2008).
Importantly, oxytocin administration increases the number of fixations and to looking time
towards the eye region during live social interaction. Further, oxytocin has been shown to
influence SCR and heart rate variability. Therefore, it is conceivable that oxytocin will not
only influence the gaze duration of the participant, but also the physiological and
neurological responses elicited by direct eye gaze.
In this study, the investigators will investigate whether oxytocin modulates the behavioural
(eye gaze and subjective ratings), neurological (EEG) and physiological (skin conductance,
heart rate and respiration) responses elicited by direct gaze.
Status | Completed |
Enrollment | 56 |
Est. completion date | May 18, 2018 |
Est. primary completion date | May 18, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: - right-handed - male - age between 18 and 35 - Normal or adjusted-to-normal vision (with lenses only) - Dutch as mother tongue Exclusion Criteria: - not right-handed - female - age below 18 or above 35 - Need to wear glasses - Dutch not as mother tongue |
Country | Name | City | State |
---|---|---|---|
Belgium | KU Leuven | Leuven |
Lead Sponsor | Collaborator |
---|---|
KU Leuven | Research Foundation Flanders |
Belgium,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in EEG asymmetry after oxytocin administration | The influence of oxytocin administration on EEG asymmetry | Average over several trials, baseline and 40 min after oxytocin or placebo administration | |
Primary | Change in skin conductance (type of electrodermal activity) response after oxytocin administration | The influence of oxytocin administration on skin conductance response | Average over several trials, baseline and 40 min after oxytocin or placebo administration | |
Secondary | Change in duration of fixations to face regions after oxytocin administration | The influence of oxytocin administration on gaze behavior (duration of fixation to upper and lower face regions) | Assesment over several trials, baseline and 40 min after oxytocin or placebo administration | |
Secondary | Change in number of fixations to face regions after oxytocin administration | The influence of oxytocin administration on gaze behavior (number of fixation to upper and lower face regions) | Assesment over several trials, baseline and 40 min after oxytocin or placebo administration |
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