Oxytocin Clinical Trial
Official title:
Monitoring the Influence of Oxytocin on Socio-communicative Sensitivity Using Fast Periodic Visual Stimulation
Verified date | July 2022 |
Source | KU Leuven |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Oxytocin (OT) is a neuropeptide that acts as a neurotransmitter and neuromodulator in the brain. Previous studies have shown that intranasal administration of OT improves social cognition and behavior (e.g. emotion recognition). In the current study, we want to gain more insight into the underlying mechanisms by which OT influences emotion recognition. More specifically, we will investigate whether intranasal administration of OT enhances the salience of social (compared to non-social) information and whether it increases the neural sensitivity for subtle socio-emotional cues, by recording scalp electroencephalography (EEG) during Fast Periodic Visual Stimulation (FPVS).
Status | Completed |
Enrollment | 31 |
Est. completion date | July 30, 2017 |
Est. primary completion date | May 30, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 30 Years |
Eligibility | Inclusion Criteria: - age between 18 and 30 years - male - right-handed - typically developing - Normal or adjusted-to-normal vision (with glasses or lenses) Exclusion Criteria: - psychiatric disorder - neurological disorder (e.g. epilepsy, migraine) - color blindness - psychoactive medication |
Country | Name | City | State |
---|---|---|---|
Belgium | Biomedical Sciences | Leuven |
Lead Sponsor | Collaborator |
---|---|
KU Leuven |
Belgium,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | side-effect questionnaire | 90 minutes after nasal spray | ||
Primary | social salience frequency-tagging FPVS | EEG recording during simultaneous (superimposed) presentation of social stimuli (faces) and non-social stimuli (objects or houses), at a frequency of 6 and 7.5Hz, respectively (counterbalanced). | random: 30-70 minutes after nasal spray | |
Primary | Oddball face detection FPVS paradigm | EEG recording during presentation of objects (at 6 Hz) and faces (inserted as an "oddball" every fifth image, thus at a frequency of 1.2 Hz) | random: 30-70 minutes after nasal spray | |
Primary | Oddball identity discrimination FPVS paradigm | EEG recording during presentation of neutral faces of the same person (same identity, presented at 6 Hz) and the face of another person (inserted as an "oddball" every fifth image, thus at a frequency of 1.2 Hz) | random: 30-70 minutes after nasal spray | |
Primary | Oddball expression generalization FPVS paradigm | EEG recording during presentation of neutral faces with different identities (at 6 Hz) and faces with an emotional expression (fear, anger, happy; inserted as an "oddball" every fifth image, thus at a frequency of 1.2 Hz) | random: 30-70 minutes after nasal spray | |
Secondary | Emotion recognition: accuracy on the Palermo Matching task (65 items) | Three faces are shown on the screen. Two of them display the same emotion and the participant has to indicate which face shows a different emotion | 80 minutes after nasal spray (after all EEG measures) | |
Secondary | resting state EEG | EEG recording, while presenting a fixation cross | 45-50 minutes after nasal spray (after two FPVS paradigms) | |
Secondary | Social responsiveness: Social Responsiveness Scale (SRS) | Self-report version of the SRS. In addition to a Total score reflecting severity of social deficits in the autism spectrum, the SRS generates scores for five Treatment subscales: Social Awareness, Social Cognition, Social Communication, Social Motivation, and Restricted Interests and Repetitive Behavior. | Baseline | |
Secondary | Social phobia: Social Phobia Inventory (SPIN) | A 17-item questionnaire that screens for, and measures, the severity of social anxiety disorder. | Baseline | |
Secondary | Attachment: State Adult Attachment Measure (SAAM) | The SAAM measures 3 different aspects of adult attachment: Security, Anxiety, Avoidance. There are 21 Likert-style questions with a score between 1 and 7 (7 for each of the three subscales). | Baseline | |
Secondary | Mood: Positive And Negative Affect Schedule (PANAS) | The Positive and Negative Affect Schedule (PANAS) comprises two mood scales, one that measures positive affect and the other which measures negative affect. It consists of 20 items (10 for each subscale). | 90 minutes after nasal spray |
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