Comparison of Volatile Anesthetics on Cerebral Oxygenation During Controlled Hypotension

Oxygen Saturation Clinical Trial

Official title:

Comparison of Effects of Sevoflurane and Desflurane on Cerebral Oxygenation During Controlled Hypotension

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02834845
• Other study ID #: 2016Sept
• Status: Completed
• Phase: Phase 4
• Start date: June 2016
• Est. completion date: August 2016

Study information

• Verified date: August 2020
• Source: Ufuk University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Controlled hypotension is a preferred method for reducing surgical bleeding during septoplasty operations however, the level of hypotension and bradycardia should not disrupt cerebral oxygenation. On this account, the investigators aim to investigate the effects of different volatile anesthetics combined with a short-acting opioid on cerebral oxygenation during controlled hypotension using near infrared spectroscopy.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 95
• Est. completion date: August 2016
• Est. primary completion date: August 2016
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Patients in American Society of Anesthesiology (ASA) classification I and II

• Patients undergoing elective septoplasty operation

Exclusion Criteria:

• Patients in ASA classification III and higher

• Emergency surgery

• Patients in New York Heart Association classification III-IV

• Patients with known allergy to drugs used in the study

Related Conditions & MeSH terms

• Hypotension
• Oxygen Saturation

Intervention

Drug:
• Sevoflurane
Sevoflurane %2-3 for general anesthesia maintenance
• Desflurane
Desflurane %6-8 for general anesthesia maintenance

Locations

Country	Name	City	State
Turkey	Ufuk University Hospital	Ankara

Sponsors (1)

Lead Sponsor	Collaborator
Ufuk University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Cerebral oxygen saturation as measured by Near Infrared Spectroscopy	The effect of sevoflurane and desflurane on NIRS values	Duration of surgery
Secondary	Total remifentanil consumption as measured in micrograms		Duration of surgery
Secondary	The effect of anesthetics on hemodynamic variables	The effects of sevoflurane and desflurane on mean arterial pressure	Duration of surgery
Secondary	The effect of anesthetics on hemodynamic variables	The effects of sevoflurane and desflurane on heart rate	Duration of surgery
Secondary	The effect of anesthetics on hemodynamic variables	The effects of sevoflurane and desflurane on bispectral index	Duration of surgery