Oxycodone Concentration in the Blood After Oral Premedication

Oxycontin Clinical Trial

Official title:

Oxycodone Concentration in the Blood After Oral Premedication

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03386318
• Other study ID #: Oxycodone premedication
• Status: Completed
• Start date: January 1, 2019
• Est. completion date: May 1, 2021

Study information

• Verified date: May 2022
• Source: Sahlgrenska University Hospital, Sweden
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Oxycodone is an opioid frequently given orally as a premedication prior to any kind of surgery. The initial studies are performed on healthy testpersons and is not given in surgery. The investigators want to explore serum concentration over time (5h) and relate this to Visual Analoge Scale (VAS) postoperatively but also to given mg/kg

Description:

Oxycodone is an opioid frequently given orally as a premedication prior to any kind of surgery. The initial studies are performed on healthy test-persons and is not given in surgery. The investigators want to explore serum concentration over time (5h) and relate this to Visual Analoge Scale (VAS) postoperatively but also to given mg/kg 20 female patients between 30 and 60 years will be included after informed consent. They will have day-surgery. The patients will receive 5 mg oxycodone if weighing less than 60 kg and 10 mg if weighing over 60 kg. Serum samples will be taken 1, 2,3,4, and 5 hours after medication intake and serum concentrations will be analyzed

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: May 1, 2021
• Est. primary completion date: May 10, 2020
• Gender: Female
• Age group: 30 Years to 60 Years

Eligibility

Inclusion Criteria:

• Females <100kg, non-opioid tolerant, day surgery and informed consent

Exclusion Criteria:

• In complying to inclusion criterias

Related Conditions & MeSH terms

• Oxycontin

Intervention

Drug:
• Oxycodone
Serum concentration per hour from 1 to 5 h

Locations

Country	Name	City	State
Sweden	Sahlgrenska UH	Mölndal	Västra Götaland

Sponsors (1)

Lead Sponsor	Collaborator
Sahlgrenska University Hospital, Sweden

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Oxycodone concentration in the blood after oral premedication	Concentration study	2 days
Primary	Oxycodone concentrations and pain after oral premedication	Visual analoge Scale	7 day