Changes in the Hormonal and Inflammatory Profile of Young Sprint- and Endurance-trained Athletes.

Overtraining Syndrome Clinical Trial

— CHIPYA  

Official title:

Changes in the Hormonal and Inflammatory Profile of Young Sprint- and Endurance-trained Athletes Following a Sports Camp

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06150105
• Other study ID #: 530/18
• Status: Completed
• Start date: February 16, 2018
• Est. completion date: December 10, 2018

Study information

• Verified date: November 2023
• Source: Poznan University of Physical Education
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

One essential element of athlete training is conditioning camps, where athletes undergo a rigorous and targeted training schedule to prepare for upcoming sporting events. During sports camps, due to the accumulation of a large number of training units, including high-intensity exercises, athletes react with post-exercise overload, acute fatigue, and overreaching which can become a chronic overtraining syndrome. Overtraining syndrome is a very specific and severe condition where overtraining without adequate rest and recovery leads to performance decrements lasting more than 2-3 months, coupled with a mood disturbance. The exact etiology and pathogenesis are unknown and actively being investigated.

During training camps the balance between training volumes and recovery is often a delicate one and, the accumulation of exercise-induced stress may exceed the capacity of both neuroendocrine and immune adaptation leading to an alteration of physiological functions, decreasing adaptation to performance, impairment of psychological processing, immunological dysfunction, and biochemical abnormalities. Moreover, there is currently a lack of biomarkers accessible to assist in diagnosing and, what's even more important - help to prevent the overtraining syndrome, except for the continued presence of unexplained underperformance despite athletes' adequate rest and recovery.

Thus, this study aims to explain how long and intensive training for endurance affects the hormonal and immune systems of young athletes.

The main questions it aims to answer are:

1. How does intense training influence hormonal and immune responses in young, trained athletes?

2. Does training specialization affect the hormonal and immune response to intense training?

Description:

Twenty-four young male and female athletes, specializing in athletics disciplines such as sprint (hurdles, 100m, 110m), and endurance: race walk, 5000m, and 10000m, volunteered to take part in this study. Investigation was held during 9 days of the training camp (preparatory period, general preparation sub-period), which was aimed at increasing the endurance and flexibility of athletes. During the training camp, all subjects occupied the same accommodations and followed the same training plan and diet schedules. The camp regime included 2 training sessions per day, lasting 4 hours per day, and a total of 21 hours per 9 days. Blood samples were taken always in the same conditions, from the antecubital veins. Participants were seated in a recumbent position for a minimum of 10 minutes before blood draws to stabilize the hydrostatic condition. Before collection of the first sample (rested baseline), participants were asked to avoid any intense exercise at least 24 hours before sampling. Next samples were taken after 4 days and after another 5 days of training camp (in total after 9 days). The concentration of catecholamines: epinephrine and norepinephrine in serum was measured as well and the responsiveness of the adrenal medulla to the sympathetic nervous activity was estimated by the ratio E/NE calculated. Also, concentrations of cortisol, hs-CRP, and myoglobin were measured and changes in blood morphology were estimated.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 24
• Est. completion date: December 10, 2018
• Est. primary completion date: February 24, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 15 Years to 17 Years

Eligibility

Inclusion Criteria:

• age 15-17 years,

• minimum of 3 years of training experience,

• specialization in anaerobic and aerobic disciplines.

Exclusion Criteria:

• presence of acute or chronic inflammation

• fever, infections, injuries

• se of any anti-inflammatory drugs.

Related Conditions & MeSH terms

• Overtraining Syndrome

Intervention

Other:
• Exercise training
Intense endurance training

Locations

Country	Name	City	State
Poland	Poznan University of Physical Education	Poznan

Sponsors (1)

Lead Sponsor	Collaborator
Poznan University of Physical Education

Country where clinical trial is conducted

Poland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in epinephrine serum level.	marker of HPA axis functioning, stress hormone.	at rest baseline (before training), after 4 - and after another 5 days of training.
Primary	Changes in norepinephrine serum level.	marker of HPA axis functioning, stress hormone.	at rested baseline (before training), after 4 - and after another 5 days of training.
Primary	Changes in cortisol serum level.	marker of HPA axis functioning, stress hormone	at rested baseline (before training), after 4 - and after another 5 days of training.
Primary	Changes in hs-CRP serum level.	marker of inflammatory response.	at rested baseline (before training), after 4 - and after another 5 days of training.
Primary	Changes in Myoglobin serum level.	marker of muscle damage	at rested baseline (before training), after 4 - and after another 5 days of training.
Secondary	Changes in blood morphology.	Morphometric measurements of blood cell.	sat rested baseline (before training), after 4 - and after another 5 days of training.
Secondary	Changes in epinephrine/norepinephrine ratio.	marker of responsiveness of the adrenal medulla to sympathetic nervous activity.	at rested baseline (before training), after 4 - and after another 5 days of training.