Local Anesthetic Treatments for Overactive Bladder

Status Terminated

Clinical Trial Summary

The purpose of this study is to determine whether alkalized lidocaine instilled into the bladder is effective in the treatment of overactive bladder (OAB).

Clinical Trial Description

Existing first-line treatments for overactive bladder are limited by requirements for chronic dosing and associated systemic side effects. Small case series suggest that bladder instillation of lidocaine may be effective in downregulating the afferent neuronal activity of a sensitized bladder, leading to elevation of the urge sensory threshold and decreasing detrusor activity. However, neither the effectiveness over placebo nor the durability of the response has been previously investigated.

Comparison(s): We propose a randomized, prospective double-blinded controlled trial to determine if a three-week trial of intravesical alkalized lidocaine instillation decreases symptoms of overactive bladder more than instillation of normal saline using a validated outcome instrument, the OAB-q. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00427648
Study type	Interventional
Source	NorthShore University HealthSystem
Contact
Status	Terminated
Phase	Phase 3
Start date	March 2006
Completion date	May 2010

View Details

See also
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