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Overactive Bladder clinical trials

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NCT ID: NCT05512039 Recruiting - Overactive Bladder Clinical Trials

Reduced-dose Botox for Urgency Incontinence Among Elder Females

RELIEF
Start date: May 12, 2023
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this study is to study the treatment of urgency urinary incontinence (UUI), specifically among women 70 years and older, by comparing reduced versus standard dose of onabotulinumtoxinA (BTX; trade name BOTOX(c)) injection in the bladder.

NCT ID: NCT05485142 Recruiting - Overactive Bladder Clinical Trials

The Treatment Efficacy of Prolotherapy in Bladder Voiding Dysfunction

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

Voiding dysfunction including overactive bladder, underactive bladder, and neuropathic bladder. Voiding dysfunction has a great impact on life quality, especially in the elderly society. The current medication for overactive bladder has limited efficacy and the patient easily to dropout the medication because of its side-effects. The underactive bladder is a new entity of voiding dysfunction, its optimal is still unknown. Sacral neuromodulation(SNM) and posterior tibial nerve stimulation(PTNS) have been applied for both overactive bladder and underactive bladder treatment and the results is promising, but the equipment of SNM or PTNS is not available in most places. Prolotherapy using glucose local injection causing inflammatory reaction to stimulate cytokine and growth factors release. Investigators combined the concepts of posterior tibial nerve stimulation and prolotherapy to treat voiding dysfunction. Investigators anticipate it maybe a new promising treatment for voiding dysfunction.

NCT ID: NCT05422625 Recruiting - Multiple Sclerosis Clinical Trials

PTNS for Female Patients Suffering From Multiple Sclerosis

PTNS-MS
Start date: January 9, 2023
Phase: N/A
Study type: Interventional

This is a pilot, single blind, randomized, sham-controlled trial to assess the benefit of PTNS in treating OAB symptoms in MS patients. The data generated by this study would provide support for a future multi-institutional, randomized prospective trial.

NCT ID: NCT05415865 Recruiting - Overactive Bladder Clinical Trials

The Effect of Local Anesthetic Solution in the Bladder Prior to Botox Injections in the Bladder

Start date: September 12, 2022
Phase: Phase 3
Study type: Interventional

The purpose of this study is to investigate the effect of Lidocaine solution versus placebo (isotonic Sodium Chloride NaCl) disposed inside the urinary bladder as intravesical anesthesia prior to onabotulinum toxin A injections in the treatment of urgency urinary incontinence.

NCT ID: NCT05362292 Recruiting - Clinical trials for Urinary Incontinence

TReating Incontinence for Underlying Mental and Physical Health

TRIUMPH
Start date: October 4, 2022
Phase: Phase 4
Study type: Interventional

The TRIUMPH study is a randomized, double-blinded, 3-arm, parallel-group trial designed to compare the effects of anticholinergic bladder therapy versus a) beta-3-adrenergic agonist bladder therapy and b) no bladder pharmacotherapy on cognitive, urinary, and other aging-related functional outcomes in ambulatory older women with urgency-predominant urinary incontinence and either normal or mildly impaired cognitive function at baseline.

NCT ID: NCT05337813 Recruiting - Overactive Bladder Clinical Trials

Effects of Low-intensity Excoporeal Shock Wave Therapy (LiESWT) on Women With Pelvic Floor Dysfunction

Start date: April 10, 2020
Phase: N/A
Study type: Interventional

1. This study needles female reproductive urinary tract, likely bladder hyperactivity, active urinary incontinence and interstitial cystitis, observation use of low-capacity seismic wave (LiESWT) therapy combined with combined platelet plasma (PRP), improved bone basin pain and female Urinary incontinence. 2. LiESWT to arousal the clitoris angiogenesis to prevent female sexual dysfunction.

NCT ID: NCT05309993 Recruiting - Overactive Bladder Clinical Trials

INvestigation of TENS Efficacy Versus Posterior Tibial Nerve Stimulation for Overactive Bladder

INTENSE
Start date: June 30, 2022
Phase: N/A
Study type: Interventional

The objective of this research is to perform a non-masked, non-inferiority randomized controlled trial to assess the quality of life (QOL) of women with idiopathic overactive bladder (OAB) before and after treatment with percutaneous tibial nerve stimulation (PTNS) or transcutaneous electrical nerve stimulation (TENS) of tibial nerve. The target population is patients with OAB who previously failed first- and second-line treatments and desire non-surgical management.

NCT ID: NCT05200923 Recruiting - Overactive Bladder Clinical Trials

Pelvic Health Electrically Evoked Recording (PEER) 2 Study

PEER 2
Start date: January 18, 2022
Phase: N/A
Study type: Interventional

To collect physiological signals at several timepoints during the therapy evaluation period.

NCT ID: NCT05158361 Recruiting - Overactive Bladder Clinical Trials

Acupuncture for Overactive Bladder in Adults

Start date: March 8, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to assess the effectiveness and safety of acupuncture for treating overactive bladder in adults.

NCT ID: NCT05099419 Recruiting - Overactive Bladder Clinical Trials

Repetitive Transcranial Magnetic Stimulation in Women With Overactive Bladder With Urgency Incontinence

Start date: October 28, 2021
Phase: Early Phase 1
Study type: Interventional

Overactive bladder (OAB) affects an estimated 16-30% of women in the US and urgency urinary incontinence (UUI) affects 7-11% of women with OAB. It is known that repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) can modulate the pelvic floor muscle activity with potential benefits for various urologic conditions. The goal of this study is to assess feasibility of rTMS as a treatment option for OAB with UUI by determining which rTMS frequency is most effective in targeting sensory components of OAB, namely urinary urgency, and also in targeting the brain network known to be involved in OAB.