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Overactive Bladder clinical trials

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NCT ID: NCT02821312 Not yet recruiting - Overactive Bladder Clinical Trials

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of DA-8010 in Healthy Subjects

Start date: June 2016
Phase: Phase 1
Study type: Interventional

This study is a Phase I, Randomised, Double-Blind, Placebo-Controlled, Dose-Escalation Study to Evaluate Safety, Tolerability and Pharmacokinetics After Single and Multiple Oral Administration of DA-8010 in Healthy Subjects.

NCT ID: NCT02704013 Not yet recruiting - Overactive Bladder Clinical Trials

Urinary Biomarkers in Overactive Bladder in Children

Start date: April 2016
Phase: N/A
Study type: Interventional

It is a single-center, prospective, interventional, single-arm study. Aim is to investigate which variables are significantly correlated with prolonged anticholinergic treatment (>6 months) in children with overactive bladder (OAB). Investigated variables will include urinary neurotrophins and inflammatory cytokines, sonographic biomarkers, symptom score scale, demographics, and urodynamic findings. Secondary aim is to analyze sensitivity and specificity of urinary biomarkers in diagnosis and management of OAB compared to urodynamics and treatment outcome.

NCT ID: NCT02389270 Not yet recruiting - Overactive Bladder Clinical Trials

Urinary Neurotrophin Levels in Healthy Children

Start date: March 2016
Phase: N/A
Study type: Observational

The aim of this study is to analyse urinary neurotrophin levels in healthy children. Urine samples will be collected at 3 different times of day (morning, noon, and evening) at urge sensation from all age groups of children who gained bladder control, i.e. from 3-18 years of age. Urinary levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) normalised to urinary creatinine will be analysed. Age and daytime related variations will be reported for both boys and girls. These results will contribute to understanding the role of neurotrophins in the physiology of lower urinary tract and pathophysiology of idiopathic and secondary hyperactive bladder in children.

NCT ID: NCT02279615 Not yet recruiting - Overactive Bladder Clinical Trials

Efficacy And Safety Of Combination Therapy For Treatment Of Overactive Bladder In Male Patients With Benign Prostatic Hyperplasia.

Start date: December 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to investigate the safety and efficacy of combination therapy involving β3-adrenoceptor agonist, mirabegron, and α-blockers for the treatment of OAB symptoms in male patients with BPH.

NCT ID: NCT01423838 Not yet recruiting - Overactive Bladder Clinical Trials

Comparison of Solifenacin and Oxybutynin in the Treatment of Overactive Bladder

Start date: September 2011
Phase: Phase 4
Study type: Interventional

Null hypothesis of the trial is that there is no difference between solifenacin and oxybutynin with respect to efficacy, side effects, patient satisfaction and quality of life measures in patients with overactive bladder.

NCT ID: NCT01409512 Not yet recruiting - Overactive Bladder Clinical Trials

Evaluation of Autonomic System Before and After Anticholinergic Treatment in Women With Overactive Bladder

Start date: September 2011
Phase: N/A
Study type: Observational

The aim of the study is to evaluate changes in autonomic nervous system following treatment with anticholinergic medication for OAB symptoms. Heart variability as a measure of the functioning of the autonomic nervous system will be recorded before and three months following treatment with solifenacin succinate 10 mg daily.