Ovarian Neoplasms Clinical Trial
Official title:
Phase 3 Randomized Study of TLK286 (Telcyta) Versus Doxil/Caelyx or Hycamtin as Third-Line Therapy in Platinum Refractory or Resistant Ovarian Cancer [ASSIST-1 (Assessment of Survival In Solid Tumors-1)]
| Verified date | May 2006 |
| Source | Telik |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | United States: Food and Drug Administration |
| Study type | Interventional |
The purpose of this study is to demonstrate superiority in survival in favor of TLK286 as compared to active control therapy with Doxil/Caelyx or Hycamtin in the intent-to-treat (ITT) populations.
| Status | Completed |
| Enrollment | 440 |
| Est. completion date | December 2006 |
| Est. primary completion date | December 2006 |
| Accepts healthy volunteers | No |
| Gender | Female |
| Age group | 18 Years and older |
| Eligibility |
Inclusion criteria include: - Considered platinum refractory or resistant according to standard criteria - Progressed during or following completion of one second-line treatment with Doxil/Caelyx or Hycamtin - Histologically or cytologically confirmed diagnosis of epithelial cancer of the ovary, fallopian tube, or primary peritoneal cancer - Measurable disease according to RECIST criteria with documented tumor progression Exclusion criteria include: - Treatment with second-line chemotherapy other than Doxil/Caelyx or Hycamtin - History of whole pelvis radiation therapy within 12 months of enrollment - Clinically significant cardiac disease - Evidence of gross hematuria at the time of study entry - Any signs of intestinal obstruction interfering with nutrition at the time of study entry - Pregnant or lactating women |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Masking: Open Label, Primary Purpose: Treatment
| Country | Name | City | State |
|---|---|---|---|
| Argentina | Hospital Italiano Regional del Sur | Bahia Blanca | Buenos Aires |
| Argentina | Complejo Medico de la Policia Federal Argentina "Churruca-Visca" | Buenos Aires | |
| Argentina | Complejo Medico de la Policia Federal Argentina "Churruca-Visca" | Buenos Aires | |
| Argentina | Hospital de Oncologia Maria Curie | Buenos Aires | |
| Argentina | Hospital Donacion Francisco Santojanni | Buenos Aires | |
| Argentina | Hospital General de Agudos "Carlos G. Durand" | Buenos Aires | |
| Argentina | Hospital Italiano de Buenos Aires | Buenos Aires | |
| Argentina | Policlinica Privada Instituto de Medicina Nuclear | Buenos Aires | |
| Argentina | Sanatorio Municipal Dr. Julio Mendez | Buenos Aires | |
| Argentina | Hospital General de Agudos Donacion F. Santojanni | Capital Federal | Buenos Aires |
| Argentina | Sociedad de Beneficencia Hospital Italiano | Cordoba | |
| Argentina | Hospital Universitario Austral | Pilar | Buenos Aires |
| Argentina | ISIS Clinica Especializada | Santa Fe | |
| Belgium | AZ-VUB Dienst Oncologie | Brussels | |
| Belgium | Cliniques Universitaires Saint-Luc | Brussels | |
| Belgium | Universitair Ziekenhuis Gent. | Gent | |
| Belgium | University Hospital Gasthuisberg | Herestraat | Leuven |
| Belgium | Centre Hospitalier Regional de la Citadelle | Liege | |
| Belgium | Algemeen Ziekenhuis Antwerpen | Lindedreef | Antwerpen |
| Belgium | Universitaire Ziekenhuis Antwerpen | Wilrijkstraat | Edegem |
| Brazil | Hospital de Clinicas de Porto Alegre | Bairro Bom Fim | Porto Alegre |
| Brazil | Hospital Luxemburgo | Belo Horizonte | MG |
| Brazil | Hospital Vera Cruz | Belo Horizonte | MG |
| Brazil | Hospital de Clinicas da Universidade Federal do Parana | Curitiba | PR |
| Brazil | Instituto do Cancer do Ceara | Fortaleza | CE |
| Brazil | Centro de Tratamento Oncologico de Londrina | Londrina | PR |
| Brazil | INCA Hospital de Oncologia Clinica | Rio de Janeiro | |
| Brazil | Hospital das Clinicas de Sao Paulo-FMUSP | Sao Paolo | SP |
| Brazil | Hospital do Cancer - A.C. Camargo | Sao Paolo | |
| Brazil | Instituto Arnaldo Vieira de Carvalho | Sao Paolo | SP |
| Brazil | Instituto de Saude e Bem Estar da Mulher | Sao Paolo | |
| Brazil | Unifesp/Epm | Sao Paulo | |
| Chile | Servicio de Oncologia-Hospital Clinico Unversidad de Chile | Independencia | Santiago |
| Chile | Clinica Santa Maria | Santiago de Chile | |
| Czech Republic | Masarykuv Onkologicky Ustav | Brno | |
| Czech Republic | Fakultni Nemocnice - Onkologicka Klinika | Doudlevecka 69 | Plzen |
| Czech Republic | Batova krajska nemocnice Zlin, prispevkova organizace, Radiodiagnosticke oddeleni | Havlickovo nabrezi | Zlin |
| Czech Republic | Batova krajska nemocnice Zlin, prispevkova organizace, Onkologicke oddeleni | Havlickovo nabrezi 600 | Zlin |
| Czech Republic | Krajska nemocnice Pardubice, Oddeleni radiacni onklogie | Kyjevska 44 | Pardubice |
| Czech Republic | Fakultni nemocnice Olomouc, Onkologicka klinika | Pardubice | Olomouc |
| Czech Republic | Fakultni nemocnice, Onkologicka klinika | Plzen | |
| Czech Republic | Vseobecna Fakultni Nemocnice - Onkologicka Klinika | Unemocnice | Praha |
| Germany | Universitatsklinikum Charite - Campus Virchow-Klinikum | Berlin | |
| Germany | St. Vincentius Kliniken | Karlsruhe | |
| Germany | St. Vincentius Kliniken - Frauenkinik | Karlsruhe | |
| Germany | St. Vincentius Kliniken - Radiology | Karlsruhe | |
| Germany | Klinikum GroBhadern-Institut fur Radiologie | Munich | |
| Germany | Klinikum GroBhadern-Zentrum fur Frauenheilkunde | Munich | |
| Germany | Universitaets-Frauenklinik Ulm | Ulm | |
| Germany | Dr. Horst-Schmidt-Kliniken GmbH | Wiesbaden | |
| Hungary | Semmelweis University, 1st Dept. of Obstetrics and Gynaecology | Baross | |
| Hungary | Uzsoki Street Hospital Dept. of Radiooncology | Budapest | |
| Hungary | Faculty of Gynaecologycal Oncology/Univ. of Debrecen | Debrecen | |
| Hungary | Baranya County Hospital | Pecs | |
| Hungary | Baranya County Hospital - Department of Oncology | Rakoczi | |
| Hungary | Baranya County Hospital - Department of Radiology | Rakoczi | |
| Hungary | SZTE, Department of Oncotherapy | Szeged | |
| Ireland | Oncology Dept., University Floor, Belfast City Hospital | Belfast | |
| Netherlands | Vrije Universiteit Medical Centre (VUMC) | HV Amsterdam | |
| Netherlands | University Medical Centre Nijmegen (UMCN) | Nijmegen | |
| South Africa | Wilgers Oncology Centre | Die Wilgers x14 | Pretoria |
| South Africa | Hopelands Cancer Centre | Overport | Durban |
| South Africa | Panorama Medical Centre | Panorama | Cape Town |
| South Africa | Eastern Cape Oncology Research Centre | Port Elizabeth | |
| South Africa | Medical and Dental Centre | Rosebank | Johannesburg |
| South Africa | Rosebank Oncology Centre | Saxonwold | Johannesburg |
| Spain | Hospital Clinic i Provincial | Barcelona | |
| Spain | Hospital Clinic i Provincial de Barcelona - Servicio de Oncologia Medica | Barcelona | |
| Spain | Hospital General de Guadalajara | Guadalajara | |
| Spain | Servicio de Oncologia | Madrid | |
| Spain | Instituto Valenciano de Oncologia (IVO) | Profesor Beltran Baguena | Valencia |
| Spain | Instituto Valenciano de Oncologia (IVO) Servicio de Oncologia | Valencia | |
| Spain | Instituto Valenciano de Oncologia (IVO) Servicio de Radiologia | Valencia | |
| Spain | Servicio Oncologia Hospital General Vall d'HebronPaseo | Vall d'Hebron | Barcelona |
| United Kingdom | St. Chad's Outpatients Unit, City Hospital | Birmingham | |
| United Kingdom | United Bristol Healthcare Trust - Bristol Oncology Centre | Bristol | |
| United Kingdom | Beatson Oncology Centre | Glasgow | |
| United Kingdom | Beatson Oncology Unit | Glasgow | |
| United Kingdom | Department of Medicine-Royal Marsden Hospital | London | |
| United Kingdom | Medical Oncology - Guy's and St. Thomas' Hospital | London | |
| United Kingdom | Department of Medical Oncology, Christie Hospital | Manchester | |
| United Kingdom | Medical Oncology (NCCT) - Newcastle General Hospital | Newcastle-upon-Tyne | |
| United Kingdom | Dorset Cancer Centre - Poole Hospital | Poole | |
| United Kingdom | Department of Cancer Medicine - Ninewells Hospital & Medical School | Scotland | Dundee |
| United Kingdom | Dept. of Med. Oncology/The Royal Marsden Hospital | Sutton | Surrey |
| United Kingdom | Velindre NHS Trust - Velindre Hospital | Wales | |
| United States | Western Washington Oncology | Aberdeen | Washington |
| United States | Abington Mem. Hospita/Rosenfield Cancer Center | Abington | Pennsylvania |
| United States | UNM Cancer Research and Treatment Center | Albuquerque | New Mexico |
| United States | Amarillo Cancer Center | Amarillo | Texas |
| United States | St. Joseph Mercy Hospital | Ann Arbor | Michigan |
| United States | Arlington Cancer Center | Arlington | Texas |
| United States | Benjamin Schwartz, M.D. | Babylon | New York |
| United States | Southern California Permanente Medical Group | Baldwin Park | California |
| United States | Sinai Cancer Institute | Baltimore | Maryland |
| United States | North Shore Oncology Hematology Associates | Barrington | Illinois |
| United States | MacNeal Cancer Center | Berwyn | Illinois |
| United States | Center for Cancer and Blood Disorders | Bethesda | Maryland |
| United States | Deaconess Billings Clinic | Billings | Montana |
| United States | Hematology & Oncology Centers Northern Rockies | Billings | Montana |
| United States | Mid Dakota Clinic | Bismarck | North Dakota |
| United States | Odyssey Research Services | Bismarck | North Dakota |
| United States | The Center for Hematology-Oncology | Boca Raton | Florida |
| United States | St. Elizabeth's Med. Ctr. | Boston | Massachusetts |
| United States | Providence Saint Joseph Medical Center | Burbank | California |
| United States | Hematology Oncology Centers of the Northern Rockies | Butte | Montana |
| United States | Western Washington Oncology | Centralia | Washington |
| United States | Carolina Center of Gynecologic Oncology, PA | Charleston | South Carolina |
| United States | Blumenthal Cancer Center | Charlotte | North Carolina |
| United States | Presbyterian Gynecologic Oncology | Charlotte | North Carolina |
| United States | Presbyterian Hospital Center for Cancer Research | Charlotte | North Carolina |
| United States | Chattanooga Oncology & Hematology Associates, P.C. | Chattanooga | Tennessee |
| United States | Memorial Hospital | Chattanooga | Tennessee |
| United States | Hematology Oncology Associates of Illinois (HOAI) | Chicago | Illinois |
| United States | Swedish Covenant Cancer Center | Chicago | Illinois |
| United States | Chippewa Falls Cancer Center | Chippewa Falls | Wisconsin |
| United States | Marilyn Norton, M. D. | Chula Vista | California |
| United States | Rosalba Rodriguez, M. D. | Chula Vista | California |
| United States | Barrett Cancer Center | Cincinnati | Ohio |
| United States | Barrett Cancer Center | Cincinnati | Ohio |
| United States | Oncology/Hematology Care, Inc. | Cincinnati | Ohio |
| United States | Oncology/Hematology Care, Inc. | Cincinnati | Ohio |
| United States | Oncology/Hematology Care, Inc. | Cincinnati | Ohio |
| United States | Oncology/Hematology Care, Inc. | Cincinnati | Ohio |
| United States | Oncology/Hematology Care, Inc. | Cincinnati | Ohio |
| United States | UC Physician's Medical Arts Bldg. | Cincinnati | Ohio |
| United States | UC Physician's Medical Arts Building | Cincinnati | Ohio |
| United States | University Hospital | Cincinnati | Ohio |
| United States | Metro Health Medical Center | Cleveland | Ohio |
| United States | MetroHealth Medical Center | Cleveland | Ohio |
| United States | Hematology Oncology Centers of the Northern Rockies | Cody | Wyoming |
| United States | Ellis Fischel Cancer Center | Columbia | Missouri |
| United States | South Carolina Oncology Associates, PA | Columbia | South Carolina |
| United States | Gynecologic Oncology | Columbus | Ohio |
| United States | Mid Ohio Oncology Hematology | Columbus | Ohio |
| United States | Mid-Ohio Oncology Hematology | Columbus | Ohio |
| United States | Mid-Ohio Oncology Hematology St. Anne's | Columbus | Ohio |
| United States | Mount Carmel Health | Columbus | Ohio |
| United States | Bay Area Research Cancer Group | Concord | California |
| United States | The Mary Imogene Bassett Hospital | Cooperstown | New York |
| United States | Covington Multicare - Oncology Clinic | Covington | Washington |
| United States | Hematology and Oncology Specialists, LLC | Covington | Louisiana |
| United States | Oncology/Hematology Care, Inc. | Crestview | Kentucky |
| United States | Dallas Oncology Consultants | Dallas | Texas |
| United States | Texas Cancer Associates | Dallas | Texas |
| United States | Danville Hematology and Oncology, Inc. | Danville | Virginia |
| United States | Wright State Univ. School of Medicine | Dayton | Ohio |
| United States | Cancer Care Specialists of Central IL | Decatur | Illinois |
| United States | Decatur Memorial Hospital | Decatur | Illinois |
| United States | The Center for Hematology-Oncology | Delray Beach | Florida |
| United States | St. Mary's Duluth Clinic | Duluth | Minnesota |
| United States | Suburban Hematology Oncology | Duluth | Georgia |
| United States | Advanced Imaging | Dunmore | Pennsylvania |
| United States | Hematology & Oncology Associates of NEPA | Dunmore | Pennsylvania |
| United States | Regional Cancer Center | Eau Claire | Wisconsin |
| United States | Cancer Care Specialists of Central IL-Crossroads Cancer Care Center | Effingham | Illinois |
| United States | Elkhart General Hospital | Elkhart | Indiana |
| United States | Michiana Hematology Oncology | Elkhart | Indiana |
| United States | Southwest Cancer Care | Escondido | California |
| United States | Dakota Cancer Institute | Fargo | North Dakota |
| United States | Odyssey Research Services | Fargo | North Dakota |
| United States | Joliet Oncology-Hematology Associates, Ltd. | Flossmoor | Illinois |
| United States | Southwest Fort Worth Cancer Center | Fort Worth | Texas |
| United States | Texas Oncology, PA | Fort Worth | Texas |
| United States | The Consultant Group | Franklin | Tennessee |
| United States | California Oncology of the Central Valley | Fresno | California |
| United States | The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Gallatin | Tennessee |
| United States | Gynecologic Oncology Research and Development | Greenville | South Carolina |
| United States | Kaiser Permanente Oncology Clinical Trials Program | Hayward | California |
| United States | The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Hermitage | Tennessee |
| United States | Memorial Regional Hospital | Hollywood | Florida |
| United States | Sheridan Clinical Research, Inc. | Hollywood | Florida |
| United States | Kaiser Permanente - Moanalua Medical Center | Honolulu | Hawaii |
| United States | Straub Clinic and Hospital | Honolulu | Hawaii |
| United States | Univ. of Hawaii, Kapiolani Medical Center for Women and Children | Honolulu | Hawaii |
| United States | Univ. of TX, MD Anderson Cancer Center | Houston | Texas |
| United States | Indiana Cancer Pavilion | Indianapolis | Indiana |
| United States | Indiana University Medical Center | Indianapolis | Indiana |
| United States | St. Vincent Gynecologic Oncology | Indianapolis | Indiana |
| United States | St. Vincent Hospital and Health Care Center | Indianapolis | Indiana |
| United States | St. Vincent Hospital and Helath Care Center | Indianapolis | Indiana |
| United States | University of Iowa | Iowa City | Iowa |
| United States | University of Iowa Hospitals and Clinics | Iowa City | Iowa |
| United States | University of Florida Health Science Center/Jacksonville | Jacksonville | Florida |
| United States | Joliet Oncology-Hematology Associates, Ltd. | Joliet | Illinois |
| United States | Fort Sanders Parkwest Medical Center | Knoxville | Tennessee |
| United States | Hall and Martin, M.D.'s, P.C. | Knoxville | Tennessee |
| United States | Saint Mary's Health System, Inc. | Knoxville | Tennessee |
| United States | Gynecologic Oncology Associates | La Jolla | California |
| United States | Grossmont Hospital | La Mesa | California |
| United States | Sharp Rees-Stealy | La Mesa | California |
| United States | North Shore Oncology Hematology Associates - Deerpath Medical Associates | Lake Forest | Illinois |
| United States | Sparrow Regional Cancer Center | Lansing | Michigan |
| United States | Nevada Cancer Center | Las Vegas | Nevada |
| United States | Suburban Hematology-Oncology Associates | Lawrenceville | Georgia |
| United States | The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Lebanon | Tennessee |
| United States | North Shore Oncology Hematology Associates | Libertyville | Illinois |
| United States | Little Rock Hematology Oncology Associates | Little Rock | Arkansas |
| United States | University of Arkansas for Medical Sciences | Little Rock | Arkansas |
| United States | LLU Faculty Medical Offices | Loma Linda | California |
| United States | LLU Faculty Meidical Offices | Loma Linda | California |
| United States | Loma Linda University Medical Center | Loma Linda | California |
| United States | David Geffen School of Medicine at UCLA | Los Angeles | California |
| United States | Women's Cancer Center - Community Hospital Los Gatos | Los Gatos | California |
| United States | Univ. of Louisville, Div. of Gynecologic Oncology | Louisville | Kentucky |
| United States | Med-Onc/Hem | Malone | New York |
| United States | Marshfield Clinic Research Foundation | Marshfield | Wisconsin |
| United States | Saint Joseph's Hospital | Marshfield | Wisconsin |
| United States | Wisconsin Rapid Cancer Center | Marshfield | Wisconsin |
| United States | Hillcrest Hospital Cancer Center | Mayfield Heights | Ohio |
| United States | North Shore Oncology Hematology Associates | McHenry | Illinois |
| United States | Merrill Cancer Center | Merrill | Wisconsin |
| United States | OncRx (Pharmacy) | Metairie | Louisiana |
| United States | Medical Consultants, Ltd. | Milwaukee | Wisconsin |
| United States | Marshfield Clinc - Lakeland Center | Minocqua | Wisconsin |
| United States | Marshfield Clinic - Lakeland Center | Minocqua | Wisconsin |
| United States | Joliet Oncology-Hematology Associates, Ltd. | Morris | Illinois |
| United States | The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Murfreesboro | Tennessee |
| United States | Southwest Cancer Care | Murrieta | California |
| United States | The Consultant Group | Nashville | Tennessee |
| United States | The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Nashville | Tennessee |
| United States | The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Nashville | Tennessee |
| United States | The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Nashville | Tennessee |
| United States | The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Nashville | Tennessee |
| United States | Jersey Shore University Medical Center | Neptune | New Jersey |
| United States | Robert Wood Johnson University Hospital | New Brunswick | New Jersey |
| United States | The Cancer Institute of New Jersey | New Brunswick | New Jersey |
| United States | Hematology-Oncology Associates of Rockland | New City | New York |
| United States | Long Island Jewish Medical Center | New Hyde Park | New York |
| United States | North Shore-Long Island Jewish Health System/Medical Center | New Hyde Park | New York |
| United States | Hematology and Oncology Specialists, LLC | New Orleans | Louisiana |
| United States | Ochsner Clinic Foundation | New Orleans | Louisiana |
| United States | Bellevue Hospital Center | New York | New York |
| United States | Comprehensive Cancer Center Medical Practice Offices | New York | New York |
| United States | Memorial Sloan Kettering Cancer Center | New York | New York |
| United States | New York University Medical Center - Tisch Hospital | New York | New York |
| United States | NYU School of Medicine | New York | New York |
| United States | Gyncologic Oncology Associates | Newport Beach | California |
| United States | Whittingham Cancer Center at Norwalk Hospital | Norwalk | Connecticut |
| United States | The Union State Bank Cancer Center at Nyack Hospital | Nyack | New York |
| United States | Kaiser Permanente Oncology Clinical Trials Program | Oakland | California |
| United States | N. County Oncology Medical | Oceanside | California |
| United States | OU Medical Center - Everett Tower | Oklahoma City | Oklahoma |
| United States | OU Physicians' Bldg. | Oklahoma City | Oklahoma |
| United States | Presbyterian | Oklahoma City | Oklahoma |
| United States | University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma |
| United States | Western Washington Oncology | Olympia | Washington |
| United States | Western Washington Oncology | Olympia | Washington |
| United States | Florida Hospital | Orlando | Florida |
| United States | Gynecologic Oncology | Orlando | Florida |
| United States | Florida Hospital Memorial Division | Ormond Beach | Florida |
| United States | Florida Hospital Memorial Division, Cancer Care Center | Ormond Beach | Florida |
| United States | Palm Beach Cancer Institute | Palm Beach Gardens | Florida |
| United States | Gynecologic Oncology Associates | Pembroke Pines | Florida |
| United States | Magee-Womens Hospital | Pittsburgh | Pennsylvania |
| United States | Hematology/Oncology Associates of Treasure Coast | Port St. Lucie | Florida |
| United States | Kaiser Permanente Nw, Oncology Research | Portland | Oregon |
| United States | Oregon Health & Science University | Portland | Oregon |
| United States | Oregon Health Science University | Portland | Oregon |
| United States | Southwest Cancer Care | Poway | California |
| United States | Kaiser Permanente Oncology Clinical Trials Program | Redwood City | California |
| United States | Diagnostic Radiology Associates | Rice Lake | Wisconsin |
| United States | Lakeview Medical Center | Rice Lake | Wisconsin |
| United States | Marshfield Clinic - Indianhead Center | Rice Lake | Wisconsin |
| United States | Gynecologic-Oncology | Rochester | New York |
| United States | Kaiser Permanente Oncology Clinical Trials Program | Roseville | California |
| United States | Women's Cancer Research Foundation, Inc. | S. Miami | Florida |
| United States | Kaiser Permanente Oncology Clinical Trials Program | Sacramento | California |
| United States | Medical Oncology Associates-SD | San Diego | California |
| United States | Sharp Healthcare Clinical Oncology Research | San Diego | California |
| United States | Sharp Memorial Hospital | San Diego | California |
| United States | Sharp Rees-Stealy | San Diego | California |
| United States | Southern California Permanente Medical Group | San Diego | California |
| United States | Kaiser Permanente Oncology Clinical Trials Program | San Francisco | California |
| United States | Kaiser Permanente Oncology Clinical Trials Program | San Rafael | California |
| United States | Kaiser Permanente Oncology Clinical Trials Program | Santa Clara | California |
| United States | Kaiser Permanente Oncology Clinical Trials Program | Santa Rosa | California |
| United States | Kaiser Permanente Oncology Clinical Trails Program | Santa Teresa | California |
| United States | Memorial Health University Medical Center | Savannah | Georgia |
| United States | Horizon's West Medical Group | Scottsbluff | Nebraska |
| United States | Community Medical Center | Scranton | Pennsylvania |
| United States | Mercy Health Partners | Scranton | Pennsylvania |
| United States | Moses Taylor Hospital | Scranton | Pennsylvania |
| United States | Viewmont Medical Services | Scranton | Pennsylvania |
| United States | Western Washington Oncology | Shelton | Washington |
| United States | Hematology Oncology of the Northern Rockies | Sheridan | Wyoming |
| United States | LSU Health Sciences Center | Shreveport | Louisiana |
| United States | Sioux Calley Clinic OBGYN Ltd. | Sioux Falls | South Dakota |
| United States | Sioux Valley Clinic Clinical Research Center | Sioux Falls | South Dakota |
| United States | Sioux Valley Clinic Oncology | Sioux Falls | South Dakota |
| United States | Sioux Valley Hospital - North Center Radiology | Sioux Falls | South Dakota |
| United States | Hematology Oncology Associates of Illinois (HOAI) | Skokie | Illinois |
| United States | Midwest Cancer Research Group, Inc. | Skokie | Illinois |
| United States | The Sarah Cannon Cancer Center/Tennessee Oncology, PLLC | Smyma | Tennessee |
| United States | Suburban Hematology Oncology | Snellville | Georgia |
| United States | Michiana Hematology Oncology | South Bend | Indiana |
| United States | Saint Joseph's Regional | South Bend | Indiana |
| United States | St. Joseph's Regional | South Bend | Indiana |
| United States | Kaiser Permanente Oncology Clinical Trials Program | South San Francisco | California |
| United States | Gynecologic Oncology Research and Development | Spartanburg | South Carolina |
| United States | Gynecology & Oncology Consultants, PC | St. Louis | Missouri |
| United States | Saint John's Mercy Hospital | St. Louis | Missouri |
| United States | St. Louis University, Dept. of Ob-Gyn and Women's Health | St. Louis | Missouri |
| United States | Hematology Oncology, P.C. | Stamford | Connecticut |
| United States | Saint Michael Hospital | Stevens Point | Wisconsin |
| United States | Allenmore Hospital - Hematology Oncology Clinic | Tacoma | Washington |
| United States | MultiCare Health System - Medical Oncology | Tacoma | Washington |
| United States | Associates in Hematology-Oncology, P.C. | Upland | Pennsylvania |
| United States | Kaiser Permanente Oncology Clinical Trials Program | Vallejo | California |
| United States | Kaiser Permanente Oncology Clinial Trials Program | Walnut Creek | California |
| United States | Wausau Cancer Center | Wausau | Wisconsin |
| United States | Palm Beach Cancer Institute | Wellington | Florida |
| United States | Good Samaritan Hospital Medical Center | West Islip | New York |
| United States | South Bay OB/GYN | West Islip | New York |
| United States | Palm Beach Cancer Institute | West Palm Beach | Florida |
| United States | Associates in Women's Health | Wichita | Kansas |
| United States | Research Support Personnel, LLC | Wichita | Kansas |
| United States | Piedmont Hematology Oncology Assoc., PA-Salem Research Group | Winston-Salem | North Carolina |
| United States | Salem Research Group, Inc. | Winston-Salem | North Carolina |
| United States | Wake Forest University School of Medicine | Winston-Salem | North Carolina |
| Lead Sponsor | Collaborator |
|---|---|
| Telik |
United States, Argentina, Belgium, Brazil, Chile, Czech Republic, Germany, Hungary, Ireland, Netherlands, South Africa, Spain, United Kingdom,
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