Ovarian Failure Clinical Trial
Official title:
Is the Concentration of Anti-Muellerian Hormon (AMH) Depending on the Menstrual Cycle?
The developement of a new, stable measurement of the Antimuellerian Hormon (AMH) together with Roche Diagnostics International (Rotkreuz, CH) shall enable an automized and timely measurement of AMH values in blood samples.
An important requirement for the use of the new measurement to determine the AMH
concentration is the stability of the AMH level over the menstrual cycle. So far the unbiased
AMH concentration is the most important argument to manage this parameter.
There are several studies, which give different professional opinions of the AMH
concentration depending on the phase of the menstrual cycle. Some authors came to the
conclusion that the AMH concentration over the menstrual cycle is constant, others described
significant fluctuations. It is unclear, if the described fluctuation is relevant for the
interpretation of the ovarian reserve. Recently it could be shown, that intraindividual
fluctuations of joung women during the menstrual cycle is stronger, which means that the
measurement of AMH in this age is less secure.
The primary goal of the study is to evaluate, if the new AMH measurement with the ElecSys
method delivers stable values over the menstrual cycle.
The secondary goal of the study is to determine whether there are any fluctuations in the
number of antral follicles as given by 3D ultrasound.
For this reason we are recruiting a group of 50 women within two categories of age to measure
eventually changes in AMH- concentration during their menstrual cycle.
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