PPK Study Based on Quantitative Pharmacology in Patients With Pamipril

Status Recruiting

Clinical Trial Summary

This is a non-intervention, prospective, one-arm, observational real-world clinical trial. The researchers plan to recruit at least 50 qualified patients. The main purpose of this study was to establish a population pharmacokinetic model of Pamiparib and to explore the correlation between its pharmacokinetic parameters and adverse reactions.

Clinical Trial Description

In recent years, the advent of poly(ADP-ribose) polymerase(PARP) inhibitors is one of the important breakthroughs in the field of tumor-targeted therapy, and its therapeutic effect on ovarian cancer is quite significant Pamiparib is a potent, selective, oral PARP 1/2 inhibitor. In preclinical models, pamiparib demonstrated PARP-DNA complex trapping, brain penetration, antitumor activity, and inhibition of PARylation. Therefore, at least 50 patients using pamiparib will be included. Before and after treatment, the laboratory examination data ，blood concentration ，combined medication and adverse events of the patients will be collected. The population pharmacokinetic model of pamiparib was established to evaluate the correlation between pharmacokinetic parameters and adverse reactions. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05848648
Study type	Observational
Source	Qianfoshan Hospital
Contact	Huang Xin
Phone	13791120711
Email	13791120711@126.com
Status	Recruiting
Phase
Start date	May 1, 2023
Completion date	June 1, 2026

View Details

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