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Clinical Trial Summary

Ovarian cancer is associated with the highest mortality of all gynecologic cancers. In patients with newly diagnosed advanced ovarian cancer after platinum-containing chemotherapy plus bevacizumab therapy, maintenance therapy with olaparib plus bevacizumab significantly prolongs progression-free survival (PFS) in the intended population and is recommended by guidelines. However, study shows those homologous recombinant repair defect (HRD) but Breast Cancer Susceptibility Gene(BRCA) wild type have limited benefit from maintenance therapy with olaparib plus bevacizumab when surgery is with residual(no-R0). Can hyperthermic intraperitoneal chemotherapy(HIPEC) improve the benefits of first-line maintenance therapy in patients with non-R0 resection, HRD? The cohort study will enroll 310 patients with HRD and no-R0 resection who conduct HIPEC during primary treatment and then have olaparib plus bevacizumab as maintenance. Follow-up period is 30 months. The primary endpoint is PFS.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05265117
Study type Observational
Source Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Contact Miao Fang Wu
Phone 13828494674
Email rich192468@163.com
Status Recruiting
Phase
Start date April 1, 2022
Completion date March 30, 2025

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