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Clinical Trial Summary

This is a phase II/III randomized controlled trial to evaluate efficacy of platinum-based chemotherapy vs conventionally prescribed non-platinum monochemotherapy in patients with platinum-resistant ovarian cancer


Clinical Trial Description

Recurrent ovarian cancer (ROC) is usually subdivided to platinum-sensitive (platinum-free interval [PFI] ≥6 mo.) and platinum-resistant ovarian cancer [PROC] (PFI <6 mo.) subtypes. Prognosis for the latter group is dismal and current guidelines recommend treating these patients with non-platinum based chemotherapy. However, the evidence behind this is quite unconvincing and according to recent data patients with non-platinum refractory platinum-resistant ovarian cancer could derive benefit from platinum rechallenge. This trial is designed for head-to-head comparison of platinum and non-platinum therapy efficacy in treatment of platinum-resistant ovarian cancer. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04055038
Study type Interventional
Source Blokhin's Russian Cancer Research Center
Contact Alexey Rumyantsev, MD
Phone +79100022255
Email alexeymma@gmail.com
Status Not yet recruiting
Phase Phase 2/Phase 3
Start date September 1, 2019
Completion date January 1, 2022

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