Ovarian Cancer Clinical Trial
— OVHIPEC-2Official title:
Phase III Randomized Clinical Trial for Stage III Epithelial Ovarian Cancer Randomizing Between Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy
stage III epithelial ovarian cancer randomizing between primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy
| Status | Recruiting |
| Enrollment | 538 |
| Est. completion date | April 1, 2026 |
| Est. primary completion date | April 1, 2025 |
| Accepts healthy volunteers | No |
| Gender | Female |
| Age group | 18 Years and older |
| Eligibility | Inclusion Criteria: - candidate for primary CRS - histological or cytological proven FIGO stage III primary epithelial ovarian, fallopian tube, or extra-ovarian cancer Exclusion Criteria: - history of previous malignancies within 5 years prior to inclusion - FIGO stage IV disease - complete primary cytoreduction is impossible - prior treatment for the current malignancy |
| Country | Name | City | State |
|---|---|---|---|
| Denmark | Rigshospitalet Copenhagen | Copenhagen | |
| France | CHU de Besancon | Besançon | |
| France | Institut Bergonié | Bordeaux | |
| France | o Institut Bergonié, Bordeaux | Bordeaux | |
| France | CHU Lille | Lille | |
| France | Centre Leon Berard, Lyon | Lyon | |
| France | CHU Lyon | Lyon | |
| France | Institut du Cancer Montpellier | Montpellier | |
| France | Institut de Cancerologie de l'Ouest, ICO Nantes) | Nantes | |
| France | Institut Curie Paris | Paris | |
| France | CHRU Strasbourg | Strasbourg | |
| France | Oncopole, Institute Universitaire du Cancer de Toulouse (IUCT Toulouse) | Toulouse | |
| Ireland | Mater Misericordiae University Hospital, Dublin | Dublin | |
| Italy | Policlinico Sant'Orsola, Bologna | Bologna | |
| Italy | Fondazione Policlinico A Gemelli IRCCS | Roma | |
| Netherlands | Amsterdam UMC | Amsterdam | |
| Netherlands | Antoni van leeuwenhoek | Amsterdam | Noord-Holland |
| Netherlands | Catharina Hospital | Eindhoven | |
| Netherlands | Medisch Spectrum Twente | Enschede | |
| Netherlands | UMCG | Groningen | |
| Netherlands | Leiden University Medical Center (LUMC) | Leiden | |
| Netherlands | Maastricht UMC+ | Maastricht | |
| Netherlands | Radboud MC | Nijmegen | |
| Netherlands | Erasmus MC | Rotterdam | |
| Netherlands | UMCU | Utrecht | |
| Sweden | Alice Bjoernlund-Larsen | Uppsala | |
| United States | City of Hope | Duarte | California |
| United States | MSKCC New York | New York | New York |
| Lead Sponsor | Collaborator |
|---|---|
| The Netherlands Cancer Institute |
United States, Denmark, France, Ireland, Italy, Netherlands, Sweden,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | overall survival | 1 year after last patient last visit | ||
| Secondary | recurrence-free survival | 1 year after last patient last visit | ||
| Secondary | adverse events | toxicity of extra treatment compared standaard treatment | 30 days after end of treatment | |
| Secondary | cost evaluation | cost evaluation based measured by quality adjusted life year | 1 year after lplv |
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02526017 -
Study of Cabiralizumab in Combination With Nivolumab in Patients With Selected Advanced Cancers
|
Phase 1 | |
| Withdrawn |
NCT05201001 -
APX005M in Patients With Recurrent Ovarian Cancer
|
Phase 2 | |
| Completed |
NCT02963831 -
A Study to Investigate ONCOS-102 in Combination With Durvalumab in Subjects With Advanced Peritoneal Malignancies
|
Phase 1/Phase 2 | |
| Not yet recruiting |
NCT06376253 -
A Phase I Study of [177Lu]Lu-EVS459 in Patients With Ovarian and Lung Cancers
|
Phase 1 | |
| Recruiting |
NCT05489211 -
Study of Dato-Dxd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)
|
Phase 2 | |
| Recruiting |
NCT03412877 -
Administration of Autologous T-Cells Genetically Engineered to Express T-Cell Receptors Reactive Against Neoantigens in People With Metastatic Cancer
|
Phase 2 | |
| Active, not recruiting |
NCT03667716 -
COM701 (an Inhibitor of PVRIG) in Subjects With Advanced Solid Tumors.
|
Phase 1 | |
| Active, not recruiting |
NCT03170960 -
Study of Cabozantinib in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors
|
Phase 1/Phase 2 | |
| Recruiting |
NCT05156892 -
Tamoxifen and SUBA-Itraconzole Combination Testing in Ovarian Cancer
|
Phase 1 | |
| Suspended |
NCT02432378 -
Intensive Locoregional Chemoimmunotherapy for Recurrent Ovarian Cancer Plus Intranodal DC Vaccines
|
Phase 1/Phase 2 | |
| Recruiting |
NCT04533763 -
Living WELL: A Web-Based Program for Ovarian Cancer Survivors
|
N/A | |
| Active, not recruiting |
NCT03371693 -
Cytoreductive Surgery(CRS) Plus Hyperthermic Intraperitoneal Chemotherapy(HIPEC) With Lobaplatin in Advanced and Recurrent Epithelial Ovarian Cancer
|
Phase 3 | |
| Withdrawn |
NCT03032614 -
Combination of Carboplatin, Eribulin and Veliparib in Stage IV Cancer Patients
|
Phase 2 | |
| Completed |
NCT02019524 -
Phase Ib Trial of Two Folate Binding Protein Peptide Vaccines (E39 and J65) in Breast and Ovarian Cancer Patients
|
Phase 1 | |
| Completed |
NCT01936363 -
Trial of Pimasertib With SAR245409 or Placebo in Ovarian Cancer
|
Phase 2 | |
| Terminated |
NCT00788125 -
Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT05059522 -
Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing
|
Phase 3 | |
| Active, not recruiting |
NCT04383210 -
Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors
|
Phase 2 | |
| Terminated |
NCT04586335 -
Study of CYH33 in Combination With Olaparib an Oral PARP Inhibitor in Patients With Advanced Solid Tumors.
|
Phase 1 | |
| Terminated |
NCT03146663 -
NUC-1031 in Patients With Platinum-Resistant Ovarian Cancer
|
Phase 2 |