Ovarian Cancer Clinical Trial
Official title:
Interventional Treatment of Ovarian Cancer With Cancer Antigen-specific Engineered Immune Effector T Lymphocytes (OC-EIEs)
This is a single-arm, open-label, phase I/II trial to evaluate the safety and efficacy of ovarian cancer-specific, engineered immune effectors (OC-EIEs) in women.
Ovarian cancer (OC) is a cancer that is derived from an ovary. The majority of OC arises from
the epithelium (outer lining) of the ovary. In 2015, OC was found in 1.2 million women and
resulted in 161,100 deaths worldwide. Among women, OC is the seventh-most common cancer and
the eighth-most common cause of cancer death. Treatment for OC consists of surgery,
chemotherapy, immunotherapy and radiotherapy. The kind of treatment depends on many factors,
including the type of OC, its stage and grade, as well as the general health of the patient.
Adoptive immunotherapy with cytotoxic T lymphocytes (CTLs) reactive with tumor antigens has
proven to be effective against many types of cancer. OC has been shown to be highly
immunogenic and therefore may respond well to innovative antigen-specific immunotherapy.
Here, through cancer antigen screening and careful target antigen evaluation, the
investigation aims to evaluate the safety and efficacy of multiple infusions of OC
antigen-specific, engineered immune effectors (EIEs) in patients with OC.
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