Ovarian Cancer Clinical Trial
Official title:
Phase I (Safety Assessment) of Durvalumab (MEDI4736) With Focal Sensitizing Radiotherapy in Platinum Resistant Ovarian, Primary Peritoneal or Fallopian Tube Epithelial Carcinoma
It is postulated that focal sensitizing radiotherapy may potentiate the effectiveness of durvalumab. The purpose of this study is to test the safety and tolerability of 2 different dose levels of focal sensitizing radiation therapy given with durvalumab.
Durvalumab is a PDL-1 inhibitor, part of class of agents (called checkpoint inhibitors)
designed to increase the ability of the immune system to recognize and work to eliminate
cancers. Checkpoint inhibitors have been studied in recurrent ovarian, primary peritoneal and
Fallopian cancers, and on their own show a low level of activity.
Radiation therapy is usually used in women with recurrent ovarian, primary peritoneal and
Fallopian cancers to palliate symptoms related to progressive disease. However, radiation is
know to modify the cancer immune environment and to release tumour antigens. These actions
may potentiate the function of immune checkpoint inhibitors.
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