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Apatinib and Etoposide in Patients With Platinum Resistant or Refractory Ovarian Cancer

Ovarian Cancer Clinical Trial

Official title:
A Phase II Study of Apatinib In Combination With Etoposide in Patients With Platinum Resistant or Refractory Ovarian Cancer

Clinical Trial Summary

The purpose of the study is to evaluate the efficacy and toxicity of apatinib in patients with platinum resistant or refractory ovarian cancer when combined with etoposide.

Clinical Trial Description

Ovarian cancer is the leading cause of death for patients with gynecologic malignancies. In most cases, the disease is diagnosed at an advanced stage and approximately 75% of patients will eventually experience disease recurrence. However, the overall response rates of second-line chemotherapy for recurrent ovarian cancer are only 20-27%. Therefore, it is important to seek alternative agent that can improve the outcome. Apatinib is a novel vascular endothelial growth factor receptor 2 tyrosine kinase inhibitor and it has been approved for the treatment of advanced gastric cancer. The preclinical studies suggest apatinib may be effective in other cancers such as ovarian cancer. Therefore, the purpose of this study is to test the efficacy and safety of the study drug apatinib when combined with a standard treatment, etoposide, for patients with platinum resistant or refractory ovarian cancer. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02867956
Study type Interventional
Source Sun Yat-sen University
Contact
Status Completed
Phase Phase 2
Start date August 10, 2016
Completion date September 10, 2019
View Details
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