Ovarian Cancer Clinical Trial
Official title:
A Proof of Concept Clinical Trial of the Combination Cediranib-Olaparib at the Time of Disease Progression on Olaparib in Ovarian Cancer
This is a phase 2 study (the second phase in testing a new drug or drug combination) to see how useful adding investigational drug cediranib to olaparib after disease progression on olaparib alone in patients with ovarian cancer.
Cediranib works by blocking (inhibiting) several specific proteins in cancer cells called the
vascular endothelial growth factor (VEGF) receptors. These proteins are important in the
formation of blood vessels to the tumor. It is believed that many tumors survive because the
blood vessels on the tumors bring oxygen and nutrients to the cancer cells which enable them
to grow. If the formation of the blood vessels is blocked, the tumor cells may die.
Olaparib works by blocking protein called poly [adenosine diphosphate-ribose] polymerase
(PARP). PARP is an important protein which tries to fix damaged deoxyribonucleic acid (DNA,
molecules that contain important instructions for the development of cells). Many cancers are
though develop from damaged DNA. By blocking PARP from fixing damaged DNA, the tumor cells
may die.
Adding cediranib to olaparib, and therefore blocking several different mechanisms for cancer
growth, may stop tumor growth.
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