Ovarian Cancer Clinical Trial
Official title:
A Study of the Efficacy of MORAb-003 in Subjects With Platinum-Sensitive Epithelial Ovarian Cancer in First Relapse
The purpose of this study is to determine if an investigational drug called MORAb-003 is useful by itself or when used with other approved cancer drugs in treating women with ovarian cancer. MORAb-003 is a monoclonal antibody directed against an antigen on most ovarian cancers.
MORAb-003 is a monoclonal antibody that has the potential to be an effective agent against
epithelial ovarian cancer (including primary fallopian tube and peritoneal adenocarcinoma)
either alone or in combination with other drugs. MORAb-003 works by a different mechanism
from other cancer therapeutics and has been shown to be well tolerated. This study allows
the opportunity to determine if MORAb-003 can work either as a single agent
1. to treat a CA125-only relapse, or
2. in combination with standard platinum and taxane chemotherapy to treat a symptomatic
relapse, and
3. to prolong a second response to chemotherapy.
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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