Ovarian Cancer Clinical Trial
Official title:
Phase II Evaluation of Three-Day Topotecan (NSC 609699) in Recurrent Platinum-Sensitive Ovarian or Primary Peritoneal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of topotecan in treating patients who have
recurrent ovarian epithelial or primary peritoneal cancer.
OBJECTIVES: I. Determine the antitumor activity of topotecan in patients with recurrent
platinum sensitive ovarian epithelial or primary peritoneal cancer. II. Determine the nature
and degree of toxicity of this treatment regimen in these patients.
OUTLINE: Patients receive topotecan IV over 30 minutes on days 1-3. Treatment continues every
3 weeks in the absence of disease progression or unacceptable toxicity. Patients are followed
every 3 months for 2 years and then every 6 months for 3 years.
PROJECTED ACCRUAL: A total of 22-60 patients will be accrued for this study.
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