Ovarian Cancer Clinical Trial
Official title:
Evaluation of Aminocamptothecin (9-AC, NSC #603071) in Recurrent, Platinum Resistant and Refractory Ovarian Cancer and Primary Peritoneal Carcinoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of aminocamptothecin in treating patients
with recurrent or refractory ovarian epithelial cancer or primary cancer of the peritoneum.
OBJECTIVES: I. Estimate the antitumor activity of aminocamptothecin colloidal dispersion in
patients with platinum-resistant recurrent or refractory ovarian cancer or primary
peritoneal carcinoma who have failed on higher priority treatment protocols. II. Determine
the nature and degree of toxicity of aminocamptothecin colloidal dispersion in this patient
population.
OUTLINE: Patients receive aminocamptothecin colloidal dispersion IV over 120 hours weekly
for two of every three weeks. Courses are repeated every 21 days in the absence of disease
progression or unacceptable toxicity. Patients are followed every 3 months for 2 years, then
every 6 months for 3 years.
PROJECTED ACCRUAL: Approximately 23-56 patients will be accrued for this study within 5-12
months.
;
Primary Purpose: Treatment
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