Outcome, Fatal Clinical Trial
Official title:
The Effect of Sugammadex on the Outcome After Colorectal Cancer Surgery
This study is retrospective study. The purpose of this study is checking the effect of sugammadex on the outcome after colorectal surgery. The outcome is compared among the 2 groups, sugammadex group and non-sugammadex group. The primary parameters of outcome are length of stay, readmission rate, postoperative complications, time interval for first successful oral intake.
Abdominal surgery, like colorectal surgery, needs more than moderate neuromuscular block
during surgery. After the surgery, reversal agent of neuromuscular blocking agent is given
almost every pateints who underwent general anesthesia.
Classic reversal agent is cholinesterase inhibitor, like pyridostigmine and neostigmine. Its
action mechanism is competetive antagonist of rocuronium. But cholinesterase inhibitor cannot
make complete reversal in moderate or deep neuromuscular block. Its incomplete reversal which
is called residual block cause respiratory complications and prolongation hospital stay.
Sugammadex has different mechanism compared to cholinesterase inhibitor. It captures
neuromuscular agent, especially rocuronium, and prevent rocuronium's action. Even in deep
neuromuscular block, sugammadex can reverse the action of rocuronium, and its reversal effect
is fater and more reliable compared to cholinesterase inhibitor.
Previous studies focused on only short term outcome of sugammadex, like postanesthetic care
unit (PACU) discharge time, respiratory complications in PACU.
But in this study, longer term outcome will be comapred between sugammadex group and
cholinesterase inhibitor group (pyridostigmine).
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