EXecution of Trans-Esophagus Echo Cardiogram in CardioPulmonary Resuscitation for Patients With Out-of-hospital Cardiac Arrest

Out-Of-Hospital Cardiac Arrest Clinical Trial

— EXECT_CPR  

Official title:

EXecution of Trans-Esophagus Echo Cardiogram in CardioPulmonary Resuscitation for Patients With Out-of-hospital Cardiac Arrest

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05907460
• Other study ID #: 109070-F
• Status: Completed
• Phase: N/A
• Start date: June 29, 2023
• Est. completion date: November 19, 2023

Study information

• Verified date: February 2024
• Source: Far Eastern Memorial Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this single center, randomized clinical control trial is to determine that changing chest compression site during cardiopulmonary resuscitation according to the examination of the TEE could increase the level of end-tidal CO2, which represents the quality of cardiopulmonary resuscitation, or not in adult patients with non-traumatic out-of-hospital cardiac arrest while comparing to those who don't receive examination of transesophageal echocardiography during cardiopulmonary resuscitation.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 132
• Est. completion date: November 19, 2023
• Est. primary completion date: November 19, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years and older

Eligibility

Inclusion Criteria:

1. Age = 20 years-old

2. Out-of-hospital cardiac arrest

3. Non-trauma

Exclusion Criteria:

1. Obvious signs of death appears, such as separation of head and body, rigor mortis, livor mortis, cankered corpse......etc.

2. Family members clearly express the willing of do not attempt resuscitation or patients who have registered advance care planning not to attempt resuscitation.

3. Patients not suitable for transesophageal ultrasound, such as patients with esophageal tumor, those whose probe cannot be placed......etc.

4. While the researcher is not available.

Related Conditions & MeSH terms

• Heart Arrest
• Out-of-Hospital Cardiac Arrest

Intervention

Device:
• transesophageal echocardiography examination during cardiopulmonary resuscitation
Perform transesophageal echocardiography in patients with out-of-hospital cardiac arrest during cardiopulmonary resuscitation and adjust the chest compression site to compress the left ventricle and avoid left ventricular outflow tract.

Locations

Country	Name	City	State
Taiwan	Far Eastern Memorial Hospital	Banqiao	New Taipei City

Sponsors (1)

Lead Sponsor	Collaborator
Far Eastern Memorial Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Rate of sustained return of spontaneous circulation (ROSC)	successful restoration and maintenance of a patient's heartbeat and blood circulation after undergoing cardiopulmonary resuscitation (CPR) for at least 20 minutes	20 minutes after ROSC
Secondary	Rate of any return of spontaneous circulation	successful restoration and maintenance of a patient's heartbeat and blood circulation after undergoing cardiopulmonary resuscitation (CPR)	1 minutes after ROSC
Secondary	Rate of survival to admission	successful restoration and maintenance of a patient's heartbeat and blood circulation for 48 hours	48 hours after ROSC
Secondary	Rate of survival to discharge	successful restoration and maintenance of a patient's heartbeat and blood circulation and able to complete treatment course till discharge	6 months after ROSC
Secondary	Rate of discharge with favorable neurological outcomes	using cerebral performance category score to measure neurologic outcomes of the patient at the time while patient's discharge. CPC1 and 2 are consider as favorable neurological outcomes, CPC3 and 4 are consider as unfavorable neurological outcomes	6 months after ROSC
Secondary	end-tidal carbon dioxide (EtCO2)	measuring end-tidal carbon dioxide during resuscitation	During resuscitation