Out-of-Hospital Cardiac Arrest Clinical Trial
Official title:
Carbon Dioxide, Oxygen and Mean Arterial Pressure After Cardiac Arrest and Resuscitation - Targeting High vs. Low Normal Values
The COMACARE trial is a pilot multicenter randomized trial to assess the feasibility and
effect on brain injury markers of targeting low or high normal arterial oxygen tension
(PaO2), arterial carbon dioxide tension (PaCO2) and mean arterial pressure (MAP) in comatose,
mechanically ventilated patients after out-of-hospital cardiac arrest. Using factorial
design, participants are randomized at admission to intensive care unit to one of eight
groups targeting either low or high normal values of PaO2, PaCO2 and MAP for 36 h. In this
way, investigators will be assessing the feasibility and effect of all three variables at the
same time.
The primary outcome is serum concentration of neuron-specific enolase (NSE) at 48 h after
cardiac arrest. Feasibility outcome is between-group separation in PaO2, PaCO2 and MAP
levels. Secondary outcomes include continuous monitoring of cerebral oxygenation, EEG and ECG
for 48 h, the levels of NSE, S100B and cardiac troponin at randomization and 24, 48 and 72 h
after cardiac arrest and neurological assessment at 6 months after cardiac arrest.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05434910 -
Blood Pressure and Cerebral Blood Flow After Cardiac Arrest
|
N/A | |
| Active, not recruiting |
NCT03700125 -
Pre-hospital ECMO in Advanced Resuscitation in Patients With Refractory Cardiac Arrest. ( SUB30 )
|
N/A | |
| Completed |
NCT02527694 -
CPR Quality Between Flexible Stretcher and Standard Stretcher in OHCA
|
N/A | |
| Completed |
NCT02899507 -
Prophylactic Antibiotics in Comatose Survivors of Out-of-hospital Cardiac Arrest
|
Phase 4 | |
| Recruiting |
NCT02184468 -
Survival Study After Out-of-hospital Cardiac Arrest
|
N/A | |
| Completed |
NCT04085692 -
Dispatcher-Assisted CPR: Low-Dose, High-Frequency Simulation-Based Training
|
N/A | |
| Recruiting |
NCT05029167 -
REstrictive Versus LIberal Oxygen Strategy and Its Effect on Pulmonary Hypertension After Out-of-hospital Cardiac Arrest (RELIEPH-study)
|
N/A | |
| Completed |
NCT04080986 -
DOuble SEquential External Defibrillation for Refractory VF
|
N/A | |
| Completed |
NCT04058925 -
Tissue Oxygenation During Cardiopulmonary Resuscitation as a Predictor of Return of Spontaneous Circulation
|
||
| Enrolling by invitation |
NCT05113706 -
Does Bystanders Emotional State Influence Dispatcher-assisted Cardiopulmonary?Resuscitation
|
||
| Completed |
NCT04219306 -
Machine Learning Assisted Recognition of Out-of-Hospital Cardiac Arrest During Emergency Calls.
|
N/A | |
| Completed |
NCT03881865 -
P25/30 SSEPs and Neurological Prognosis After Cardiac Arrest
|
||
| Recruiting |
NCT04993716 -
Epidemiological Study on the Management of Out-of-hospital Cardiac Arrest Survivors in Champagne ArDEnnes
|
||
| Completed |
NCT05062785 -
Dose-Finding Study of Intranasal Insulin in Healthy Participants Insulin in Healthy Participants
|
Phase 1 | |
| Recruiting |
NCT06122337 -
Systemic Evaluation of the Etiologies of Young Adults With Non-traumatic Out-of-hospital Cardiac Arrest
|
||
| Not yet recruiting |
NCT04584463 -
Factors Associated With CPC 1-2 in 110 Patients Admitted in French ICU for a Myocardial Infarction Complicated by an OHCA.
|
||
| Recruiting |
NCT03355885 -
Early-onset Pneumonia After Out-of-hospital Cardiac Arrest
|
N/A | |
| Recruiting |
NCT05132387 -
Wroclaw Out-Of-Hospital Cardiac Arrest Registry
|
||
| Recruiting |
NCT02827422 -
A Prospective, Multicenter Registry With Targeted Temperature Management After Out-of-hospital Cardiac Arrest in Korea
|
N/A | |
| Completed |
NCT02646046 -
Combining Performance of Call EMS and Simultaneous Chest Compressions in a Lone Rescuer CPR
|
N/A |