Antifungal Potential of Moringa Olifera Against Otomycosis

Otomycosis Clinical Trial

Official title:

Antifungal Potential of Moringa Olifera-loaded Nanoparticles Against Otomycosis; Preparation, Characterization, and Clinical Evaluation

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04768829
• Other study ID #: S85Motic
• Status: Completed
• Phase: Early Phase 1
• Start date: February 18, 2021
• Est. completion date: December 1, 2021

Study information

• Verified date: March 2022
• Source: Deraya University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

patients with Otomycosis were recognized by an ENT specialist. 20 patients were distributed randomly into two groups. The first group will be treated with Nystatin ear drops twice daily. The second group will be treated with Moringa ear drops. patients will be examined endoscopically by the ENT specialist. patient's swabs will be isolated and analyzed by ELISA.

Description:

Inclusion criteria:

(1) Otomycosis .

Exclusion criteria:

1. tympanic membrane perforation;

2. concurrent immune suppression,

3. and concurrent bacterial infection.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: December 1, 2021
• Est. primary completion date: September 15, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 50 Years

Eligibility

Inclusion Criteria:

1. Otomycosis

2. ear inflammation

Exclusion Criteria:

1. tympanic membrane perforation

2. concurrent immune suppression,

3. concurrent bacterial infection.

Related Conditions & MeSH terms

• Otomycosis

Intervention

Drug:
• Moringa oleifera leaf 10mg/100ml
ear drops
• Ear Drop
plain ear drop formulation without moringa

Locations

Country	Name	City	State
Egypt	Soad A. Mohamad	Minya	??????

Sponsors (2)

Lead Sponsor	Collaborator
Deraya University	Minia University

Country where clinical trial is conducted

Egypt, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of participants recovered with clear endoscopic examination	Number of participants recovered with clear endoscopic examination	one week
Primary	Identification of different microorganisms infected ear	Patients swabs (microorganisms concentration)	up to 1 month