Antimicrobial Stewardship in Community Pharmacy

Status Completed

Clinical Trial Summary

Acute otitis media (AOM) is the most common indication for antibiotics for Canadian paediatric patients. As the gatekeepers of safe and effective prescription pharmacotherapy, community pharmacists are well positioned to influence and optimize antibiotic use. The purpose of this project is to develop, implement, and evaluate an antimicrobial stewardship program in the community pharmacy setting that aims to optimize antibiotic use for AOM. This nonrandomized pre-post study includes children aged 6 months to 12 years presenting with an antibiotic prescription for AOM at two community pharmacies in Toronto, Ontario. Participants are excluded if they exhibit signs/symptoms of mastoiditis, have an additional indication for systemic antibiotics, or parents/guardians cannot consent in English. The multifaceted AMS intervention includes pharmacist education, a clinical decision support tool, a parent/guardian questionnaire, and individualized monthly audit and feedback with each pharmacist. Prescriptions are reviewed and adapted by the pharmacist to optimize congruence with 2016 Canadian Paediatric Society AOM guidelines. The primary outcome is the percentage change in guideline congruence attributable to pharmacist intervention. This study will provide insight into the opportunities and barriers of developing large-scale antimicrobial stewardship programs for community pharmacies.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04219553
Study type	Interventional
Source	University of Toronto
Contact
Status	Completed
Phase	N/A
Start date	May 25, 2017
Completion date	December 1, 2017

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04016051` - Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections	Phase 3
Completed	`NCT02452164` - Family MobilePhone Otoscopy in Diagnostics of Otitis Media	N/A
Completed	`NCT01199016` - Effect of Prevnar 13 on Ear Infections in Children	Phase 4
Terminated	`NCT00778063` - Study Using Dexmedetomidine to Decreases Emergence Delirium in Pediatric Patients	N/A
Completed	`NCT00195611` - Study of Streptococcus Pneumoniae in Nose and Throats of Infants With Acute Otitis Media	Phase 4
Recruiting	`NCT03722160` - Clinical Study of the Solo Tympanostomy Tube Device	N/A
Recruiting	`NCT04447521` - Surveillance of Non-invasive Streptococcus Pneumoniae Infections in Belgium
Active, not recruiting	`NCT05127161` - Broad Implementation of Outpatient Stewardship	N/A
Completed	`NCT02600559` - Open-Label Study of OTO-201 in Pediatric Subjects With a History of Otitis Media Requiring Tympanostomy Tubes	Phase 3
Completed	`NCT01444391` - inVENT-visIOn Study	N/A
Enrolling by invitation	`NCT01437436` - The Effect of Obesity on Ventilation Tube Insertion	N/A
Completed	`NCT01003210` - Homeopathic Ear Drops for Otitis Media Study	N/A
Completed	`NCT00768534` - Study Evaluating Microbiological Analysis of Spontaneous Draining Acute Otitis Media	N/A
Recruiting	`NCT00393159` - The Influence of The Ear Popper on Serous Otitis Media and on the Accompanying Conductive Hearing Loss in Children	Phase 4
Completed	`NCT00617682` - Maternal Immunization To Prevent Infant Otitis Media	Phase 1/Phase 2
Withdrawn	`NCT00956748` - N-Acetylcysteine as an Adjunct for Refractory Chronic Suppurative Otitis Media	Phase 4
Withdrawn	`NCT01908764` - Pharmacokinetic Study of AL-60371 Otic Suspension in Pediatric Subjects Following Tympanostomy Tube Surgery	Phase 1
Recruiting	`NCT01619462` - Safety and Immunogenicity of 10-valent and 13-valent Pneumococcal Conjugate Vaccines in Papua New Guinean Children	Phase 3
Completed	`NCT02616458` - The Impact of Ear Pain Anticipatory Guidance Counseling on Otitis Related Visits in a Low Income Population	N/A
Completed	`NCT00781521` - Safety and Efficacy of Floxin Otic Solution in the Treatment of Acute Otitis Media in Children	Phase 3