Study Using Dexmedetomidine to Decreases Emergence Delirium in Pediatric Patients — PED-DEX  

Otitis Media Clinical Trial

Official title: Intranasal Dexmedetomidine Decreases Emergence Delirium in Pediatric Patients After Sevoflurane Based General Anesthesia

Status Terminated

Clinical Trial Summary

The purpose of this study is to evaluate the use of intranasal dexmedetomidine to reduce the incidence of emergence delirium during general sevoflurane anesthesia in a pediatric population receiving pressure equalization tubes in one or more ear.

Clinical Trial Description

Emergence delirium has been described as a dissociated state of consciousness in which the child is irritable, uncompromising, uncooperative, incoherent, inconsolably crying, moaning, kicking or thrashing. The children can run the gambit from restlessness and incoherence to combative and psychotic. The incidence of emergence agitation or delirium is 80% after a procedure with sevoflurane-induced anesthesia.

Dexmedetomidine has been shown to have sedative and analgesic effects. In the pediatric population, it has been shown to provide sedation for radiographic procedures. Intravenously, it is has been shown to decrease emergence delirium following sevoflurane based anesthesia. The ability to administer a medication intranasally might solve the problem of emergence delirium and emergence agitation posed by the young patients undergoing myringotomy and tube placement. ;

Related Conditions & MeSH terms

• Delirium
• Emergence Delirium
• Otitis Media

• NCT number: NCT00778063
• Study type: Interventional
• Source: Ochsner Health System
• Status: Terminated
• Phase: N/A
• Start date: September 2008
• Completion date: March 2013