Otitis Media With Effusion Clinical Trial
Official title:
Study of the Expression of MMPs (Metalloproteinase Matricial) in OME (Otitis Media With Effusion) in Children Under Twelve Years Old With Atrophy of the Eardrum
Metalloproteinases (MMPs) constitute a family of endopeptidases that cleaves the
extracellular matrix as collagen included in the eardrum. Activity of MMP has been shown in
some otitis media with effusion (OME) fluids. These enzymes could be directly linked to the
prosnostic of OME as it may damage the eardrum and leads to tympanic atrophy.
The main goal of the study is to find out the correlation between activity of MMPs and
tympanic atrophy. The investigator will also study if there is any clinical predictive
factors in relation to the level of MMPs.
The investigator will include 35 children under 12 years old with OME and who need
tympanostomy or tube placement under general anesthesia. Middle ear effusion will be
collected, divided in two and frozen.
The investigator will perform ELISA tests to measure the level of MMP2 MMP9 MMP7 et TIMP2
(inhibitor of MMPs). The investigator want to compare the level of MMPs between healthy
eardrum and atrophic membrane.
Clinical data will be collected such as age, gender, chronicity of the OME, quality of the
eardrum and middle ear effusion type to see if there is any difference when MMPs level is
higher.
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