Clinical trial NCT03896217 - References

Secondary Progressive Multiple Sclerosis — Simvastatin in Secondary Progressive Multiple Sclerosis

Citation(s)

•   Antonopoulos AS, Margaritis M, Shirodaria C, Antoniades C
  Translating the effects of statins: from redox regulation to suppression of vascular wall inflammation. Thromb Haemost. 2012 Nov;108(5):840-8. doi: 10.1160/TH12-05-0337. Epub 2012 Aug 7.
•   Bennett JL, de Seze J, Lana-Peixoto M, Palace J, Waldman A, Schippling S, Tenembaum S, Banwell B, Greenberg B, Levy M, Fujihara K, Chan KH, Kim HJ, Asgari N, Sato DK, Saiz A, Wuerfel J, Zimmermann H, Green A, Villoslada P, Paul F; GJCF-ICC&BR
  Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography. Mult Scler. 2015 May;21(6):678-88. doi: 10.1177/1352458514567216. Epub 2015 Feb 6.
•   Chataway J, Schuerer N, Alsanousi A, Chan D, MacManus D, Hunter K, Anderson V, Bangham CR, Clegg S, Nielsen C, Fox NC, Wilkie D, Nicholas JM, Calder VL, Greenwood J, Frost C, Nicholas R
  Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial. Lancet. 2014 Jun 28;383(9936):2213-21. doi: 10.1016/S0140-6736(13)62242-4. Epub 2014 Mar 19.
•   D'haeseleer M, Beelen R, Fierens Y, Cambron M, Vanbinst AM, Verborgh C, Demey J, De Keyser J
  Cerebral hypoperfusion in multiple sclerosis is reversible and mediated by endothelin-1. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5654-8. doi: 10.1073/pnas.1222560110. Epub 2013 Mar 18.
•   De Keyser J, Steen C, Mostert JP, Koch MW
  Hypoperfusion of the cerebral white matter in multiple sclerosis: possible mechanisms and pathophysiological significance. J Cereb Blood Flow Metab. 2008 Oct;28(10):1645-51. doi: 10.1038/jcbfm.2008.72. Epub 2008 Jul 2.
•   Endres M, Laufs U, Huang Z, Nakamura T, Huang P, Moskowitz MA, Liao JK
  Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8880-5. doi: 10.1073/pnas.95.15.8880.
•   Fox RJ, Thompson A, Baker D, Baneke P, Brown D, Browne P, Chandraratna D, Ciccarelli O, Coetzee T, Comi G, Feinstein A, Kapoor R, Lee K, Salvetti M, Sharrock K, Toosy A, Zaratin P, Zuidwijk K
  Setting a research agenda for progressive multiple sclerosis: the International Collaborative on Progressive MS. Mult Scler. 2012 Nov;18(11):1534-40. doi: 10.1177/1352458512458169. Epub 2012 Aug 23.
•   Giannopoulos S, Katsanos AH, Tsivgoulis G, Marshall RS
  Statins and cerebral hemodynamics. J Cereb Blood Flow Metab. 2012 Nov;32(11):1973-6. doi: 10.1038/jcbfm.2012.122. Epub 2012 Aug 29.
•   Grecescu M
  Optical coherence tomography versus visual evoked potentials in detecting subclinical visual impairment in multiple sclerosis. J Med Life. 2014 Oct-Dec;7(4):538-41. Erratum In: J Med Life. 2014 Oct-Dec;7(4):627.
•   Greenwood J, Heasman SJ, Alvarez JI, Prat A, Lyck R, Engelhardt B
  Review: leucocyte-endothelial cell crosstalk at the blood-brain barrier: a prerequisite for successful immune cell entry to the brain. Neuropathol Appl Neurobiol. 2011 Feb;37(1):24-39. doi: 10.1111/j.1365-2990.2010.01140.x.
•   Greenwood J, Mason JC
  Statins and the vascular endothelial inflammatory response. Trends Immunol. 2007 Feb;28(2):88-98. doi: 10.1016/j.it.2006.12.003. Epub 2007 Jan 2.
•   Greenwood J, Steinman L, Zamvil SS
  Statin therapy and autoimmune disease: from protein prenylation to immunomodulation. Nat Rev Immunol. 2006 May;6(5):358-70. doi: 10.1038/nri1839.
•   Greenwood J, Walters CE, Pryce G, Kanuga N, Beraud E, Baker D, Adamson P
  Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis. FASEB J. 2003 May;17(8):905-7. doi: 10.1096/fj.02-1014fje. Epub 2003 Mar 5.
•   Haendeler J, Hoffmann J, Zeiher AM, Dimmeler S
  Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells: a novel vasculoprotective function of statins. Circulation. 2004 Aug 17;110(7):856-61. doi: 10.1161/01.CIR.0000138743.09012.93. Epub 2004 Aug 2.
•   Harry R, Gegg M, Hankey D, Zambarakji H, Pryce G, Baker D, Calder V, Adamson P, Greenwood J
  Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction. J Immunol. 2005 Feb 15;174(4):2327-2335. doi: 10.4049/jimmunol.174.4.2327.
•   Huang-Link YM, Al-Hawasi A, Lindehammar H
  Acute optic neuritis: retinal ganglion cell loss precedes retinal nerve fiber thinning. Neurol Sci. 2015 Apr;36(4):617-20. doi: 10.1007/s10072-014-1982-3. Epub 2014 Oct 14.
•   Kutzelnigg A, Lucchinetti CF, Stadelmann C, Bruck W, Rauschka H, Bergmann M, Schmidbauer M, Parisi JE, Lassmann H
  Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain. 2005 Nov;128(Pt 11):2705-12. doi: 10.1093/brain/awh641. Epub 2005 Oct 17.
•   Laufs U, La Fata V, Plutzky J, Liao JK
  Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation. 1998 Mar 31;97(12):1129-35. doi: 10.1161/01.cir.97.12.1129.
•   Liao JK
  Beyond lipid lowering: the role of statins in vascular protection. Int J Cardiol. 2002 Nov;86(1):5-18. doi: 10.1016/s0167-5273(02)00195-x.
•   Lublin F, Miller DH, Freedman MS, Cree BAC, Wolinsky JS, Weiner H, Lubetzki C, Hartung HP, Montalban X, Uitdehaag BMJ, Merschhemke M, Li B, Putzki N, Liu FC, Haring DA, Kappos L; INFORMS study investigators
  Oral fingolimod in primary progressive multiple sclerosis (INFORMS): a phase 3, randomised, double-blind, placebo-controlled trial. Lancet. 2016 Mar 12;387(10023):1075-1084. doi: 10.1016/S0140-6736(15)01314-8. Epub 2016 Jan 28. Erratum In: Lancet. 2017 Jan 21;389(10066):254.
•   Magliozzi R, Howell O, Vora A, Serafini B, Nicholas R, Puopolo M, Reynolds R, Aloisi F
  Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain. 2007 Apr;130(Pt 4):1089-104. doi: 10.1093/brain/awm038.
•   Mahad DH, Trapp BD, Lassmann H
  Pathological mechanisms in progressive multiple sclerosis. Lancet Neurol. 2015 Feb;14(2):183-93. doi: 10.1016/S1474-4422(14)70256-X.
•   Mason JC
  Statins and their role in vascular protection. Clin Sci (Lond). 2003 Sep;105(3):251-66. doi: 10.1042/CS20030148.
•   Miller E, Mrowicka M, Saluk-Juszczak J, Ireneusz M
  The level of isoprostanes as a non-invasive marker for in vivo lipid peroxidation in secondary progressive multiple sclerosis. Neurochem Res. 2011 Jun;36(6):1012-6. doi: 10.1007/s11064-011-0442-1. Epub 2011 Mar 12.
•   Mraiche F, Cena J, Das D, Vollrath B
  Effects of statins on vascular function of endothelin-1. Br J Pharmacol. 2005 Mar;144(5):715-26. doi: 10.1038/sj.bjp.0706114.
•   Neuhaus O, Hartung HP
  Evaluation of atorvastatin and simvastatin for treatment of multiple sclerosis. Expert Rev Neurother. 2007 May;7(5):547-56. doi: 10.1586/14737175.7.5.547.
•   Pahan K, Sheikh FG, Namboodiri AM, Singh I
  Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. J Clin Invest. 1997 Dec 1;100(11):2671-9. doi: 10.1172/JCI119812.
•   Paling D, Thade Petersen E, Tozer DJ, Altmann DR, Wheeler-Kingshott CA, Kapoor R, Miller DH, Golay X
  Cerebral arterial bolus arrival time is prolonged in multiple sclerosis and associated with disability. J Cereb Blood Flow Metab. 2014 Jan;34(1):34-42. doi: 10.1038/jcbfm.2013.161. Epub 2013 Sep 18.
•   Paraskevas KI
  Statin treatment for rheumatoid arthritis: a promising novel indication. Clin Rheumatol. 2008 Mar;27(3):281-7. doi: 10.1007/s10067-007-0806-8. Epub 2007 Dec 8.
•   Schmeer C, Kretz A, Isenmann S
  Statin-mediated protective effects in the central nervous system: general mechanisms and putative role of stress proteins. Restor Neurol Neurosci. 2006;24(2):79-95.
•   van der Most PJ, Dolga AM, Nijholt IM, Luiten PG, Eisel UL
  Statins: mechanisms of neuroprotection. Prog Neurobiol. 2009 May;88(1):64-75. doi: 10.1016/j.pneurobio.2009.02.002. Epub 2009 Feb 21.
•   Vollmer T, Key L, Durkalski V, Tyor W, Corboy J, Markovic-Plese S, Preiningerova J, Rizzo M, Singh I
  Oral simvastatin treatment in relapsing-remitting multiple sclerosis. Lancet. 2004 May 15;363(9421):1607-8. doi: 10.1016/S0140-6736(04)16205-3.
•   Walters CE, Pryce G, Hankey DJR, Sebti SM, Hamilton AD, Baker D, Greenwood J, Adamson P
  Inhibition of Rho GTPases with protein prenyltransferase inhibitors prevents leukocyte recruitment to the central nervous system and attenuates clinical signs of disease in an animal model of multiple sclerosis. J Immunol. 2002 Apr 15;168(8):4087-4094. doi: 10.4049/jimmunol.168.8.4087.
•   Weber MS, Youssef S, Dunn SE, Prod'homme T, Neuhaus O, Stuve O, Greenwood J, Steinman L, Zamvil SS
  Statins in the treatment of central nervous system autoimmune disease. J Neuroimmunol. 2006 Sep;178(1-2):140-8. doi: 10.1016/j.jneuroim.2006.06.006. Epub 2006 Jul 24.
•   Xu G, Fitzgerald ME, Wen Z, Fain SB, Alsop DC, Carroll T, Ries ML, Rowley HA, Sager MA, Asthana S, Johnson SC, Carlsson CM
  Atorvastatin therapy is associated with greater and faster cerebral hemodynamic response. Brain Imaging Behav. 2008 Jun 1;2(2):94. doi: 10.1007/s11682-007-9019-7.
•   Young RP, Hopkins RJ
  Update on the potential role of statins in chronic obstructive pulmonary disease and its co-morbidities. Expert Rev Respir Med. 2013 Oct;7(5):533-44. doi: 10.1586/17476348.2013.838018.
•   Yuan C, Zhou L, Cheng J, Zhang J, Teng Y, Huang M, Adcock IM, Barnes PJ, Yao X
  Statins as potential therapeutic drug for asthma? Respir Res. 2012 Nov 24;13(1):108. doi: 10.1186/1465-9921-13-108.

A Double-blind, Randomised, Placebo-controlled Single-site Study of High Dose Simvastatin Treatment for Secondary Progressive Multiple Sclerosis: Impact on Vascular Perfusion and Oxidative Damage

Details for clinical trial NCT03896217