Osteoradionecrosis Clinical Trial
Official title:
Advances in the Management of Mandibular Osteoradionecrosis: Pentoxifylline and Tocopherol as Medical Treatment
Mandibular osteoradionecrosis, despite its low incidence, remains being the most problematic
and irreversible complication after head and neck radiotherapy with no medical treatment to
limit or reduce symptoms.
Different clinical trials have shown a significant scientific evidence that the treatment
with pentoxifylline + tocopherol achieves a certain effectiveness in the treatment of the
tissue fibrosis. This study proposes to use this drugs to determine if there is healing of
mandibular osteoradionecrosis and/or a symptomatic improvement as well.
Mandibular osteoradionecrosis which occurs after the use of radiation therapy for the
treatment of head and neck cancer remains being the most problematic and irreversible
complication despite its low incidence with no medical treatment to limit or reduce symptoms.
Clinical trials conducted to date have shown a significant scientific evidence that the
treatment with pentoxifylline + tocopherol achieves a certain effectiveness in the treatment
of the tissue fibrosis that have been irradiated based on the properties of this drugs in
increased tissue oxygenation and their antioxidant effect.
The aim of this study is to determine if there is a clinical improvement of mandibular
osteoradionecrosis using Pentoxifylline in combination with Tocopherol as treatment because,
currently, there is no effective treatment to achieve bone healing and/or a symptomatic
improvement.
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