Osteopenia Clinical Trial
Official title:
Effect of Whole-Body Vibration on Plasma Sclerostin Level in Healthy Young Adult Women
The aim of this study is to investigate effect of whole-body vibration on plasma sclerostin
level in healthy young adult women.
Fifteen healthy young adult women are planned to include in this study. All cases will be
trained on a whole-body vibration (WBV) platform (Power Plate) 5 times a week for one week
period. Training duration will be short at the beginning but progressed slowly.
The amplitude of vibration will be 2 mm and the frequency of the vibration will be 40 Hz.
The subjects will be asked to report negative side effects or adverse reactions in their
training diary.
Previbration and postvibration (just after, 10.minute and 30.minute) levels of plasma
sclerostin will be measured on first, second and fifth day of experiment. Sclerostin levels
will be measured by human sclerostin ELISA kit.
Whole-body vibration has a strong osteogenic effect. The cyclic mechanical loading to the
bone stimulates the osteocytes.
Sclerostin, the protein product of the SOST gene, is an osteocyte-specific cysteine
knot-secreted glycoprotein that is a potent inhibitor of bone formation. Sost/sclerostin
levels have been reported to be reduced by mechanical stimulation.
The aim of this study is to investigate effect of whole-body vibration on plasma sclerostin
level in healthy young adult women.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT04754711 -
Interest of Nutritional Care of Children With Sickle Cell Disease on Bone Mineral Density and Body Composition
|
N/A | |
| Active, not recruiting |
NCT05066477 -
A Clinical Trial Investigating the Effect of Salmon Bone Meal on Bone Mass Among Osteopenic Women
|
N/A | |
| Terminated |
NCT01902186 -
Bone Mineral Density Changes in HIV-positive Females With Osteopenia Switching to Raltegravir
|
Phase 4 | |
| Not yet recruiting |
NCT01397838 -
Safety Study of an Oral Pro-boneTM, Administered to Post Menopausal Osteopenic Women
|
Phase 1 | |
| Completed |
NCT01439139 -
Bone UltraSonic Scanner (BUSS): Validation Study
|
N/A | |
| Completed |
NCT01222026 -
Systematic Treatment After Successful Surgical Treatment for Primary Hyperparathyroidism With Strontium Ranelate
|
Phase 4 | |
| Completed |
NCT01152580 -
Melatonin Osteoporosis Prevention Study
|
Phase 1 | |
| Completed |
NCT00789425 -
Investigating the Effect of Standardized Olive Extract on Bone Turnover Markers in Postmenopausal Women
|
Phase 2 | |
| Completed |
NCT00655681 -
Prevention of Post Operative Bone Loss in Children
|
N/A | |
| Completed |
NCT00463268 -
Osteoporosis Prevention With Low Dose Alendronate
|
Phase 3 | |
| Completed |
NCT00798473 -
Zoledronate for Osteopenia in Pediatric Crohn's
|
Phase 3 | |
| Active, not recruiting |
NCT00076050 -
Using Soy Estrogens to Prevent Bone Loss and Other Menopausal Symptoms
|
Phase 3 | |
| Completed |
NCT00226031 -
Optimal Management of Women With Wrist Fractures
|
N/A | |
| Enrolling by invitation |
NCT04752098 -
A Study to Assess Metabolic Bone Disease of Prematurity Using an Acoustic Method
|
N/A | |
| Completed |
NCT04720833 -
Effect of Dried Plum on Bone and Markers of Bone Status in Men
|
N/A | |
| Recruiting |
NCT05541432 -
Finding the Optimal Resistance Training Intensity For Your Bones
|
N/A | |
| Active, not recruiting |
NCT05405894 -
Efficacy of Zoledronic Acid to Prevent Bone Loss Following Denosumab Discontinuation
|
||
| Completed |
NCT05457036 -
Evaluation of the Effect of Spry Belt Treatment on Bone Turnover Marker Profile
|
N/A | |
| Completed |
NCT04040010 -
The Effects of Bovine Colostrum in Bone Metabolism in Humans
|
N/A | |
| Completed |
NCT02731820 -
Efficacy of Potassium Citrate in the Treatment of Postmenopausal Osteopenia
|
N/A |