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NCT01102751 Clinical Trial

Serum FGF-23 and Vitamin D Deficiency

Osteomalacia Clinical Trial

Official title:
Effects Of Vitamin D Replacement Therapy on Serum FGF-23 Concentrations in Vitamin D Deficient Women In Short Term

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01102751
Other study ID # Istanbul University
Secondary ID Research Fund
Status Completed
Phase N/A
First received April 12, 2010
Last updated April 12, 2010

Study information
Verified date August 2009
Source Istanbul University
Contact n/a
Is FDA regulated No
Health authority Turkey: Ethics Committee
Study type Observational

Clinical Trial Summary

We aimed to determine the effect of vitamin D replacement therapy on serum FGF-23 concentrations in vitamin D deficient women and to compare the FGF-23 concentrations of vitamin D deficient patients with healthy subjects and patients with genetically-determined hypophosphatemic rickets.

Description:

Study group was composed of vitamin D deficient females (n =18, mean age 29.1±9.9 yrs), vitamin D sufficient healthy females (control group; n = 19, mean age 28.5±5.2 yrs) and patients with genetically-determined hypophosphatemic rickets (n=13, mean age 26.5±15.1 yrs). Groups were compared for serum FGF-23, 1,25 dihydroxy vitamin D3, calcium, phosphate, bone turnover markers, intact parathyroid hormone and urinary excretion of calcium and phosphate. Vitamin D deficient group was re-evaluated after a standard treatment regimen.

Recruitment information / eligibility
Status Completed
Enrollment 0
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 9 Years to 44 Years
Eligibility Inclusion Criteria:

- Serum 25OHD Vitamin <30 ng/mL for group 1

- Serum 25OHD Vitamin >30 ng/mL for control group

Exclusion Criteria:

- Receiving medication(s) affecting bone metabolism

- History of gastrointestinal disease and malabsorption

- History of renal and liver disease

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Turkey Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Endocrinology and Metabolism Istanbul

Sponsors (1)
Lead Sponsor Collaborator
Istanbul University

Country where clinical trial is conducted

Turkey, 

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