Osteoarthrosis Clinical Trial
Official title:
Effect of Preoperative Intravenous High Dose Methylprednisolone on Glucose Homeostasis in Patients Scheduled for Total Hip- and Knee-arthroplasty
This study evaluates the pathophysiological effects of a single dose of Methylprednisolone
administered prior to total hip- and knee-arthroplasty surgery. The investigators examine
the effect on blood glucose homeostasis.
Half of participants will receive intravenous Solu-Medrol 125 mg, while the other half will
receive placebo.
The investigators hypothesize that the glucose homeostasis remains equally stable in the
group receiving Methylprednisolone as in the group receiving placebo.
The anti-inflammatory effects of glucocorticoids are well known. The beneficial effects on
postoperative pain, postoperative nausea and vomiting are well-documented.
Glucocorticoid might change the glucose metabolism as it induces insulin-resistance.
Glucocorticoids are known to reduce the insulin-mediated glucose uptake by reducing the
muscle glycogen synthase activity.
The effect of a single high dose of glucocorticoid is poorly described in the literature,
and therefore calls for further investigation.
This study is embedded in a primary study registrated as: NCT02319343
For further details please view the EudraCT registration:
EudraCT nr.: 2014-003395-23
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