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Osteoarthrosis clinical trials

View clinical trials related to Osteoarthrosis.

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NCT ID: NCT02222740 Completed - Osteoarthrosis Clinical Trials

A Safety, Tolerability and Pharmacokinetic Dose Escalation Study of HC-ER in Patients With Osteoarthritis Pain

Start date: September 2002
Phase: Phase 2
Study type: Interventional

Assess the safety, tolerability and pharmacokinetics of multiple doses of 10, 20, 30, and 40 mg of Hydrocodone Bitartrate Extended Release (HC-ER)capsules taken with food at steady state, in subjects with chronic, moderate to severe osteoarthritis (OA) pain.

NCT ID: NCT02071745 Completed - Osteoarthrosis Clinical Trials

Navigated Total Knee Arthroplasty, the Correlation to CT Scans and Clinical Results

Start date: July 2013
Phase: N/A
Study type: Observational

Total knee replacement is one of the most commonly performed orthopedic procedures. As of 2010, about 600,000 total knee replacements were being performed annually in the United States and these numbers are rising. The normal knee joint functions as a complex hinge allowing primarily flexion and extension, rotation and gliding. The knee joint is made up of three compartments, the lateral, medial and anterior (patellofemoral). Damage to the cartilage of one or more compartments may be the result of osteoarthritis (idiopathic or post-traumatic), inflammatory arthritis (rheumatoid,psoriatic, etc.), a-vascular necrosis, tumors, or congenital deformities. Osteoarthritis and rheumatoid arthritis are the causes of the overwhelming majority of total joint arthroplasties. A successful Total knee arthroplasty(TKA) surgery includes: an accurate alignment( the mechanical axis in axial and rotational planes), as well as significant pain relief which improves function and quality of life. Incorrect alignment can lead to abnormal wear, premature mechanical loosening of the components and patellofemoral problems. The common techniques for Total knee replacement are: 1. Conventional method TKR 2. CT/MRI-based preoperative navigated TKR 3. Image-free intraoperative navigated TKR In our research we focus on the 3rd method using the Orthopilot navigation system Aesculap®, Tutlingen, Germany. This system is an active PC based guiding system that helps the surgeon decide on the accurate alignment and orientation of the implant and cutting surfaces of the bone and thus avoid incorrect alignment. We aim to compare between pre-operative and post-operative lower limb alignment (mechanical axis) in Aesculap based TKA using serview CT. Furthermore, we will try to examine the existence of a correlation between the CT scans and the Orthopilot navigation system output and assess the clinical outcome of the patient postoperatively. Our Hypothesis is that the intra-operative navigation system is accurate and correlated to CT images results, moreover, allows the surgeon to achieve a good mechanical axis and high clinical outcome,

NCT ID: NCT01940692 Completed - Osteoarthrosis Clinical Trials

Topical and Intravenous Administration of TXA Are Equally Effective in DAA THA

Start date: July 2014
Phase: Phase 2
Study type: Interventional

Through a randomized controlled trial, we will compare the intravenous administration of tranexamic acid with the intra-articular application after a total hip arthroplasty through direct anterior approach. - RCT, prospective study - Academic-monocentric study - Clinical outcome measurements The postoperative blood loss will be the primary outcome. Secondary outcomes are 1. The rate of perioperative and postoperative blood transfusion 2. The number of blood units transfused 3. The length of hospital stay 4. Perioperative given intravenous isotonic fluid The Null-hypothesis is that there is no significant difference in postoperative blood loss between intra-articular and intravenous administration of TXA.

NCT ID: NCT01603017 Completed - Osteoarthrosis Clinical Trials

Nuclear Magnetic Resonance Therapy in Knee Osteoarthrosis

Start date: September 2007
Phase: N/A
Study type: Interventional

Nuclear Magnetic Resonance Therapy (NMRT) is gaining as a novel mode of therapy in osteoarthrosis. A prospective double blind randomised study of 100 patients was conducted to investigate efficacy of NMRT in the treatment of mild to moderate osteoarthrosis (OA) of the knee joint. The null hypothesis was that there is no benefit of NMRT over placebo in mild to moderate oteoarthosis of the knee.

NCT ID: NCT01443975 Completed - Clinical trials for Total Hip Arthroplasty

Clinical Evaluation on the Use of the X-pander Device

X-Pander
Start date: September 2011
Phase: N/A
Study type: Observational

The purpose of this study is to clinically evaluate the use of the x-pander device.

NCT ID: NCT00860873 Completed - Osteoarthrosis Clinical Trials

Effectiveness of Glucosamine + Chondroitin in Osteoarthrosis

Start date: October 2009
Phase: Phase 3
Study type: Interventional

This study objective is to check the non-inferiority of the 2 formulations produced by EMS when compared with the same substances and pharmaceuticals forms of the product Condroflex (Zodiac), by promoting the relief of osteoarthrosis symptoms such as pain, stiffness and functional capacity that will be periodically measured by using the "Visual Analog Scale" of pain (VAS) and the questionnaire of Lequesne.

NCT ID: NCT00291499 Completed - Osteoarthrosis Clinical Trials

Efficacy Study of Condrosulf in the Treatment of Symptomatic OA of the Hand

Start date: June 2005
Phase: Phase 3
Study type: Interventional

The goal of the present study is to investigate the effectiveness of Condrosulf® 800 mg tablets vs. placebo once a day for 6 months in the symptomatic treatment of finger joint osteoarthritis. Primary endpoints of the study are the evaluation of global spontaneous pain (Huskisson's Visual Analogue Scale: VAS) and the score of Dreiser's algo-functional index (FIHOA) during the treatment with the tested product, Condrosulf®, versus placebo.

NCT ID: NCT00192699 Completed - Osteoarthrosis Clinical Trials

Bimetric-10: Investigation of Patients Who Have Underwent Total Hip Arthroplasty With a Cemented Bi-Metric Stem

Start date: January 2004
Phase: N/A
Study type: Observational

This is a 10 year follow-up investigation of patients who have underwent total hip arthroplasty with a cemented Bimetric stem.

NCT ID: NCT00116948 Completed - Osteoarthrosis Clinical Trials

A Comparison of Two Total Hip Replacements: Hip Resurfacing System Versus Mallory-Head/Exeter

Start date: January 2005
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare two total hip replacement systems: Hip Resurfacing System (ReCap) versus Mallory-Head/Exeter.