Osteoarthritis Clinical Trial
Official title:
Development of a Microfluidic Organotypic Model to Evaluate Monocyte Transendothelial Migration to the Joint in Obese Osteoarthritic Patients
Osteoarthritis (OA) is the fastest growing cause of disability worldwide due to population
ageing and increasing obesity incidence. Obese individuals have a higher risk of OA
insurgence and severe progression due to several risk factors, including their systemic
inflammation state and superior migratory ability of monocytes. In the present project we aim
at the development of a novel 3D microfluidic organotypic model resembling the joint to
investigate the migration ability of monocytes from obese and non-obese OA patients.
We hypothesize that monocytes from obese OA patients display superior migration ability and a
specific pattern of chemokine surface receptors compared to monocytes from non-obese OA
patients. We also hypothesize that these features lead to a superior infiltration of
monocytes/macrophages to the synovial membrane in obese OA patients. Based on this, our main
aim will be to highlight differences between Mo from obese and non-obese OA patients in terms
of surface receptors and migration ability in a microfluidic organotypic model.
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