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Study of the Laboratory-based Evaluation of the Degrees of Activity of Osteoarthritis

Osteoarthritis Clinical Trial

Official title:
Study of the Laboratory-based Evaluation of the Degrees of Activity of Medium and Large Joint Osteoarthritis

Clinical Trial Summary

This study evaluates laboratory-based method to estimate the degrees of activity of medium and large joint osteoarthritis.

Clinical Trial Description

Osteoarthritis (OA) is a chronic progressive disease, characterized by degradation of joint cartilage, synovial inflammation and joint dysfunction. This study evaluates laboratory-based method to estimate the degrees of activity of medium and large joint OA. Samples of synovial fluid (SF) from the patients with the OA (ICD-10 codes: M15, M16 and M17) will be assessed for T-cell subsets, msast cells, fibroblast-like synoviocytes (FLS) and macrophage-like synoviocytes (MLS) by flow cytometry. Subpopulations of blood T-cells involved in the inflammation will also be assayed. Standard clinical investigation will be performed and the results will be used to estimate the laboratory criteria or degrees of activity of medium and large joint OA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03164070
Study type Observational
Source The Republican Research and Practical Center for Epidemiology and Microbiology
Contact
Status Completed
Phase
Start date July 1, 2016
Completion date December 29, 2018
View Details
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