Osteoarthritis Clinical Trial
Official title:
Phenotype/Genotype Correlation in a Family With Early Onset Osteoarthritis: Contribution of Genetic in the Diagnosis and Early Management of Patients.
This study will investigate the genes responsible for osteoarthritis. Individuals with
osteoarthritis known or suspected to be caused by a gene mutation (change) may be eligible
for this study. Family members may also participate.
Patients will talk with investigators who will explain the study and its possible
implications for the patient and family and answer questions. The patient's medical records
will be reviewed, a personal and family history will be taken, and a physical examination
will be done. Two procedures may be done including blood sampling (which will be used for
DNA (genetic) studies) and X-rays (to define osteoarthritis grade).
If no known mutations responsible for osteoarthritis will be detected, participating family
members will be interviewed by telephone about their personal and family health history and
will have a blood sample drawn for DNA testing, and X-rays.
We will investigate the clinical manifestations and molecular genetic defects of human osteoarthritis. Families with osteoarthritis of known or suspected genetic basis will be enrolled. Individuals will undergo clinical assessment and genetic analyses for the purpose of: 1) definition and characterization of phenotype, 2) determination of the natural history of the disorder, and 3) genotype/phenotype correlation. Genetic linkage studies may be performed for disorders in which the genetic bases is not yet known. ;
Observational Model: Family-Based, Time Perspective: Cross-Sectional
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