Osteoarthritis Clinical Trial
— msmOfficial title:
The Effect of Methyl-Sulphonyl-Methane on Osteoarthritis and Joint Cartilage Associated With the Degeneration of the Chondrocyte
To delineate the effect of MSM on osteoarthritis
Status | Recruiting |
Enrollment | 100 |
Est. completion date | October 2013 |
Est. primary completion date | September 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 40 Years and older |
Eligibility |
Inclusion Criteria: - Knee and hip OA - men and women >45 years of age Exclusion Criteria: - any other type of arthritis - chronic pain syndrome - arthroscopic surgery in the past 8 months - intra-articular corticosteroidsin the past 8 months - hyaluronic acid injections in the past 8 months - narcotic pain killers use - renal or hepatic disease - body mass index (BMI) >45 kg/m2 - cancer |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Supportive Care
Country | Name | City | State |
---|---|---|---|
Greece | G. Papanikolaou Hospital | Thessaloniki |
Lead Sponsor | Collaborator |
---|---|
G.Papanikolaou Research Group |
Greece,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of participants with improved Mobility | Randomized, double-blind, placebo-controlled trial including an intervention and a placebo group. One hundred men and women, with hip and/or knee OA were divided in 2 groups. Intervention was either MSM 3 gr twice a day for 26 weeks (6 gr/day total) for one group and placebo for the other. Outcomes measured were the Western Ontario and McMaster University Osteoarthritis Index visual analogue scale (WOMAC) | 26 weeks | Yes |
Secondary | Pain Scores on the Visual Analog Scale | On the same two groups (MSM and Placebo)we measured the improvement of quality of life through pain relief as measured by use of SF-36 (overall health-related quality of life) | 26 weeks | Yes |
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