Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading

Osteoarthritis Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01090375
• Other study ID #: H-KF-306126
• Status: Completed
• Phase: Phase 0
• First received: March 18, 2010
• Last updated: March 18, 2010
• Start date: August 2008

Study information

• Verified date: March 2010
• Source: Bispebjerg Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Denmark: The Danish National Committee on Biomedical Research Ethics
• Study type: Interventional

Clinical Trial Summary

In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise. The aim of the present study was, by applying the microdialysis technique, to monitor markers of cartilage breakdown and inflammation in 2 different positions of the knee (inside and in the inner part of the knee capsule) in a group of human females with knee osteoarthritis over a period of 3 hours.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 0
• Est. primary completion date: March 2009
• Gender: Female
• Age group: 55 Years to 75 Years

Eligibility

Inclusion Criteria:

• verified osteoarthritis (x-ray)of the knee, female,

Exclusion Criteria:

• dementia, inflammatory diseases, regular pain medication

Study Design

Intervention Model: Parallel Assignment, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Exercise
• Osteoarthritis

Intervention

Other:
• Exercise

• Non Exercise

Locations

Country	Name	City	State
n/a

Sponsors (5)

Lead Sponsor	Collaborator
Bispebjerg Hospital	Danish Ministry of Health, Internal Affairs, Danish National Research Council, The Danish Medical Research Council, The Danish Rheumatism Association