Effect of Intraarticular Steroids on Bone Turnover in Osteoarthritis

Osteoarthritis Clinical Trial

Official title: Effect of Intraarticular Steroids on Bone Turnover in Osteoarthritis

Status Enrolling by invitation

Clinical Trial Summary

Oral and nasal steroids may enhance osteoporosis by suppressing bone formation. Intra-articular steroids may also suppress bone formation, however, the duration or relationship to a steroid dose has not been established. It is hypothesized that intra-articular steroids suppress bone formation transiently, returning to pretreatment levels within four weeks in subjects with osteoarthritis.

Clinical Trial Description

Oral and nasal steroids may enhance osteoporosis by suppressing bone formation. Intra-articular steroids may also suppress bone formation, however, the duration or relationship to a steroid dose has not been established. It is hypothesized that intra-articular steroids suppress bone formation transiently, returning to pretreatment levels within four weeks in subjects with osteoarthritis. The purpose of the study is to determine if intra-articular steroids suppress markers of bone formation or resorption in osteoarthritis patients and whether these markers may be modified by Vitamin D or DEXA bone density status ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Supportive Care

Related Conditions & MeSH terms

• Osteoarthritis

• NCT number: NCT00682357
• Study type: Interventional
• Source: University of Kansas Medical Center
• Status: Enrolling by invitation
• Phase: N/A
• Start date: May 2008
• Completion date: May 2010