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NCT00669201 Clinical Trial

Wrist Cartilage - High Resolution in Vivo MR T2 Mapping- a Feasibility Study

Osteoarthritis Clinical Trial

Official title:
Wrist Cartilage - High Resolution in Vivo MR T2 Mapping- a Feasibility Study

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT00669201
Other study ID # SHEBA-08-4912-IE-CTIL
Secondary ID
Status Recruiting
Phase N/A
First received April 28, 2008
Last updated April 29, 2008
Start date December 2007

Study information
Verified date April 2008
Source Sheba Medical Center
Contact n/a
Is FDA regulated No
Health authority Israel: Israeli Health Ministry Pharmaceutical Administration
Study type Observational

Clinical Trial Summary

Purpose:Evaluate the feasibility of T2 cartilage mapping on MRI of the wrist and correlate with T2 mapping of knee cartilage.

Study protocol: Phase 1. 10 healthy volunteers, Phase 2. 10 volunteers with osteoarthritis of the wrist, Phase 3. 50 patients for studies for routine MR of the wrist.

MRI protocol: 3 T unit((Signa EXITE HDx),T1, T2 and T2 mapping sequences on axial and coronal orientation.

Recruitment information / eligibility
Status Recruiting
Enrollment 70
Est. completion date
Est. primary completion date
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Both
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- Phase 1. Age:18-40

- Phase 2: No age limit, known OA on pre-existing X-rays

- Phase 3: No age limit, routine MRI of the wrist

Exclusion Criteria:

- Phase 1, 2: wrist trauma/surgery

- All phases: any contraindication for MR: eg metals, claustrophobia, etc.

Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
Israel Sheba Medical Center , Diagnostic Imaging Dept Tel Hashomer
Israel Sheba Medical Center, Diagnostic Imaging Dept Tel Hashomer

Sponsors (1)
Lead Sponsor Collaborator
Sheba Medical Center

Country where clinical trial is conducted

Israel, 

References & Publications (3)

Glaser C. New techniques for cartilage imaging: T2 relaxation time and diffusion-weighted MR imaging. Radiol Clin North Am. 2005 Jul;43(4):641-53, vii. Review. — View Citation

Mosher TJ, Dardzinski BJ, Smith MB. Human articular cartilage: influence of aging and early symptomatic degeneration on the spatial variation of T2--preliminary findings at 3 T. Radiology. 2000 Jan;214(1):259-66. — View Citation

Recht MP, Goodwin DW, Winalski CS, White LM. MRI of articular cartilage: revisiting current status and future directions. AJR Am J Roentgenol. 2005 Oct;185(4):899-914. Review. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary wrist bone cartilage thickness can be measured and stratification can be observed on T2 mapping with correlation to T2 mapping of the knee cartilage Within MRI completion (20 minutes) No
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