Osteoarthritis Clinical Trial
Official title:
Exploratory Study of Determinants of Early Functional Outcome Following Reconstructive Knee Surgery
This exploratory study will quantify and describe patient-reported and objective measures of sensorimotor, neuromuscular, psychophysiological and genotypical performance capabilities and levels of habitual physical activity prior to and around the time of surgery.
Despite the positive outcomes of total knee arthroplasty (TKA) surgery on symptoms such as
pain, perceived function and health-related quality of life (QoL) current research
highlights the persistent deleterious effects of retained aberrant neuromuscular alterations
on physical function, which may also directly impact falls risk. Importantly, observed
increases in neuromuscular deficits that occur prior to surgery track through into the
post-operative stage with functional limitations that are sustained and which can persist at
least one year after surgery. Clearly, it is crucial to strive to identify modifiable
factors that might successfully ameliorate this pathophysiological process prior to surgery,
reduce post surgical impairments and which also accelerate recovery.
Among other determinants that might contribute towards understanding of optimal functional
recovery following reconstructive knee surgery is the influence of genes. The evaluation of
specific genotypes and subsequent protein expression might provide further insight into the
extent of genetic influence. For example, it is not yet known whether patients with specific
genotypes experience an accelerated recovery. Currently, there is a paucity of research on
the influence of gene-environment interactions on an individual's response to physical
conditioning.
The proposed research will be an exploratory study, involving four repeated-measures
assessments from 10 weeks prior to surgery to 12 weeks after surgery. This study offers a
novel evaluation of the overall patterning of changes and will quantify and describe
patient-reported and objective measures of sensorimotor, neuromuscular, psychophysiological
performance capabilities, genotypes and levels of habitual physical activity.
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