Clinical Trials Logo

Clinical Trial Summary

Vasoplegic syndrome is characterized clinically by reduced systemic vascular resistance and normal or increased cardiac output. It is principally observed in cardiovascular and orthopedic interventions and is characterized by a systemic inflammatory response with the inability of the vascular endothelial muscles to contract and a resistance to the action of vasoactive drugs. This event extends the length of stay in the critical care area due to the need of vasoactive drugs.

The investigators aim to assess the standardized application of midodrine in postoperative patients without sepsis and need of vasoactive drugs in order to reduce the length of stay in critical care area and for extension in hospital.


Clinical Trial Description

Midodrine is an alpha 1 receptor agonist used usually in cases of hypotension helping to increase blood pressure. The main indication is orthostatic hypotension but there are other clinical conditions where this medicament is often used like hypotension by dialysis, hepatorenal syndrome and after carotid artery stenting.

Vasoplegic syndrome coul be interpreted as a variant of orthostatic hypotension that happens usually after surgical interventions. It produces a loss of systemic vascular resistance due to inflammatory reaction without any signs of infection.

The investigators aim to conduct a randomized, double-blind, single-center, placebo-controlled study of midodrine in patients who present postoperative vasoplegia with no active signs of sepsis but need of vasoactive drugs (Noradrenalin). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04440085
Study type Interventional
Source Bürgerspital Solothurn
Contact Marcos Delgado, MD
Phone +4132627
Email marcos.delgado@spital.so.ch
Status Not yet recruiting
Phase Phase 4
Start date September 14, 2020
Completion date September 14, 2021

See also
  Status Clinical Trial Phase
Completed NCT02705755 - TD-9855 Phase 2 in Neurogenic Orthostatic Hypotension (nOH) Phase 2
Recruiting NCT05941819 - ARC Therapy to Restore Hemodynamic Stability and Trunk Control in People With Spinal Cord Injury N/A
Completed NCT05529147 - The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly
Recruiting NCT02897063 - Effects of Midodrine and Droxidopa on Splanchnic Capacitance in Autonomic Failure Phase 1
Completed NCT02726776 - Suspension Syndrome N/A
Completed NCT01559675 - Trial Comparing Low Dose and High Dose Steroids in Patients Undergoing Colorectal Surgery N/A
Recruiting NCT03732716 - Sarcopenia and Orthostatic Hypotension
Recruiting NCT05621460 - The Effect of Water Carbonation on Orthostatic Tolerance N/A
Completed NCT02632318 - Dawn Simulation and Postural Hypotension Phase 4
Completed NCT05729724 - Effect of Pharmacological Interventions on Systolic Blood Pressure Drops (SynABPM 2 Proof-of-concept)
Completed NCT03721393 - Data Collection - Of Syncope Tilt Table Testing Study
Completed NCT01030874 - Orthostatic Hypotension Treatment on Rehab Unit N/A
Completed NCT01362751 - Orthostatic Hypotension in Elderly Nursing Home Residents N/A
Completed NCT01223391 - Abdominal Compression in Orthostatic Hypotension N/A
Completed NCT00248807 - A Study of Blood Pressure and Blood Supply to the Brain in Persons With a Spinal Cord Injury. N/A
Terminated NCT00137319 - Impedance Threshold Device Tilt Study N/A
Completed NCT05233865 - Hemodynamic Effects During Land vs Water Exercise for Older Adults With Orthostatic Hypotension N/A
Suspended NCT01370512 - Droxidopa / Pyridostigmine in Orthostatic Hypotension Phase 2
Recruiting NCT00452712 - Orthostatic Hypotension in Children With Acute Febrile Illness Phase 2
Recruiting NCT04493372 - Deciphering Preserved Autonomic Function After Spinal Cord Injury N/A