Treatment of Orthostatic Hypotension

Orthostatic Hypotension Clinical Trial

Official title: Treatment of Hypotensive Patients Having a Unique Pattern of Autonomic Symptoms

Status Terminated

Clinical Trial Summary

The purpose of this study is to try different medications in patients with low blood pressure and other problems with their involuntary (autonomic) nervous system. The pharmacological trials in this study will perhaps lead to more effective treatment. The protocol includes single dose trials, dose-selection trials, 5-day trials and chronic (approximately 2 months) trials, although only dose-selection trials were consistently performed and have results presented.

Clinical Trial Description

We see many patients at the Autonomic Dysfunction Center who can be given a fairly definitive diagnosis, e.g., Orthostatic Intolerance, Pure Autonomic Failure, Multiple System Atrophy, and Baroreflex Failure. However, some patients present with a unique constellation of symptoms of autonomic dysfunction so that they do not fit into a diagnostic category. We hypothesize that a genetic cause exists in some of these patients. We further propose that our comprehensive evaluation of these patients will provide us with information on the pathophysiology of their condition and assist us in optimizing their treatment. ;

Related Conditions & MeSH terms

• Autonomic Nervous System Diseases
• Dopamine Beta-Hydroxylase Deficiency
• Hypotension
• Hypotension, Orthostatic
• Nervous System Diseases
• Orthostatic Hypotension
• Orthostatic Intolerance
• Primary Dysautonomias

• NCT number: NCT00581477
• Study type: Interventional
• Source: Vanderbilt University Medical Center
• Status: Terminated
• Phase: Phase 2/Phase 3
• Start date: January 2004
• Completion date: December 2020