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NCT00580996 Clinical Trial

Water and the Gastropressor Response - Tachyphylaxis

Orthostatic Hypotension Clinical Trial

Official title:
Water and the Gastropressor Response - Tachyphylaxis (Specific Aim 1.2)

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT00580996
Other study ID # 060547
Secondary ID Vanderbilt Disco
Status Active, not recruiting
Phase N/A
First received
Last updated
Start date July 2006
Est. completion date December 2025

Study information
Verified date September 2023
Source Vanderbilt University Medical Center
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

We are studying the effects of oral water ingestion in patients with orthostatic hypotension. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier.

Description:

We are studying the effects of oral water ingestion in patients with orthostatic hypotension. This has been termed the Gastropressor Response. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier. In this 2 day study, subjects will be asked to drink with 1 oz or 16 oz of water in the morning followed a few hours later by 16 oz water while the blood pressure is monitored. On the 2nd day, the other dose of water will be given to start, with 16 oz again as the second dose.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 20
Est. completion date December 2025
Est. primary completion date December 2025
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - orthostatic hypotension (fall in BP>20/10 mmHg) - pressor response to water in other studies - Age 18-80 years Exclusion Criteria: - pregnancy

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• water high dose
water 16 oz PO x 1
• water tiny dose
water 1 oz PO x 1

Locations
Country Name City State
United States Vanderbilt University Nashville Tennessee

Sponsors (1)
Lead Sponsor Collaborator
Satish R. Raj

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary blood pressure 2nd water intervention
Secondary heart rate 2nd intervention
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