Droxidopa in Treating Patients With Neurogenic Hypotension

Orthostatic Hypotension Clinical Trial

Official title: Study of Droxidopa in Patients With Neurologic Hypotension

Status Completed

Clinical Trial Summary

Please note that the continuation study can be found at http://clinicaltrials.gov/show/NCT00633880.

RATIONALE: Neurogenic hypotension is a fall in blood pressure that occurs when one moves from a lying down to a standing position or after eating a meal. It causes one to feel dizzy, light headed, and weak. Neurogenic hypotension is caused by a problem in the part of the nervous system that controls such functions as heart rate and blood pressure. Droxidopa, a drug that may increase blood pressure, may be an effective treatment for neurogenic hypotension.

PURPOSE: Clinical trial to study the effectiveness of droxidopa in treating patients who have neurogenic hypotension.

Clinical Trial Description

PROTOCOL OUTLINE:

Patients receive escalating doses of droxidopa or placebo for 7-14 days. Patients undergo blood pressure measurements hourly in both supine and standing positions. ;

Study Design

Primary Purpose: Treatment

Related Conditions & MeSH terms

• Hypotension
• Hypotension, Orthostatic
• Multiple System Atrophy
• Orthostatic Hypotension
• Shy-Drager Syndrome

• NCT number: NCT00004478
• Study type: Interventional
• Source: Office of Rare Diseases (ORD)
• Status: Completed
• Phase: N/A
• Start date: March 1999
• Completion date: March 2006