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Feasibility and Tolerance of Nivolumab Neoadjuvant Immunotherapy in High Risk HPV Driven Oropharynx Cancer — IMMUNEBOOST  

Oropharynx Cancer Clinical Trial

Official title:
A Multicenter, Randomized, Open Label, Phase II Study Evaluating the Feasibility and Tolerance of Nivolumab Neoadjuvant Immunotherapy in High Risk HPV Driven Oropharynx Cancer

Clinical Trial Summary

The aim of this research is to study the feasibility of neoadjuvant treatment before chemoradiation in "high risk" HPV-driven Oropharynx cancer

Clinical Trial Description

Methodology: Patient screened wil be randomized 2:1 between 2 arms: - Experimental arm: Nivolumab 2 infusions (2 weeks part) before standard of care chemoradiation for 7 weeks with cisplatin at week 1, 4, and 7 - Control arm: Standard of care chemoradiation for 7 weeks with cisplatin at week 1, 4, and 7 Primary Objective: To assess the feasibility and tolerance of neoadjuvant nivolumab treatment before chemoradiation in "high-risk" HPV-driven Oropharynx Cancer ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03838263
Study type Interventional
Source UNICANCER
Contact
Status Active, not recruiting
Phase Phase 2
Start date July 25, 2019
Completion date November 2024
View Details
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