Oropharyngeal Cancer Clinical Trial
Official title:
18F-FDG-PET Guided Dose-Painting With Intensity Modulated Radiotherapy in Oropharyngeal Tumours (FiGaRO), A Phase 1 Pilot Study
Treatment of cancers of the head and neck, including oropharyngeal tumours, usually consist
of a combination of radiotherapy and chemotherapy, although surgery may also play a part.
Radiotherapy works by using the high energy x-rays to destroy cancer cells. Head and neck
cancers often respond well to radiotherapy in the first instance and a proportion of patients
will be cured by this treatment. However, not all of the cancer cells are destroyed by the
combination of radiotherapy and chemotherapy and, in some patients, the cancer does come
back.
Studies have suggested that more efficient killing of cancer cells, and therefore, better
cure rates, can be achieved by increasing the radiotherapy dose. However, in the past, this
was not possible due to side effects. Intensity Modulated Radiotherapy (IMRT) is a new
radiotherapy delivery technique that allows better shaping of the dose to the areas that need
irradiating with the potential for fewer side effects. If the investigators use IMRT to
deliver an intentionally higher dose of radiation (called a boost) to small selected areas
whilst, at the same time giving standard treatment doses to the remaining areas, this
approach is called IMRT dose-painting. These selected areas can be identified by a scan
called 18F-FDG-PET (18F-fluorodeoxyglucose-positron emission tomography, also known as a
'PET' scan) which is a type of scan that can give information about the activity of a cancer.
The purpose of this study is to find out whether the investigators can use IMRT dose-painting
to boost the dose to the region inside a tumour which appears most active on 18F-FDG-PET. If
this study shows that this approach is well-tolerated, then the investigators may be able to
improve cure rates with this treatment. This would need to be tested in a subsequent study.
n/a
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