Oro-cecal Transit Time Clinical Trial
Official title:
Orocecal Transit Time and Fermentation in IBS
Orocecal transit time is studied in individuals with irritable bowel syndrome (IBS) of both the constipation-dominant, diarrhea-dominant, and mixed form using the lactulose hydrogen breath test for orocecal transit time through the gut. Data are compared to those of healthy volunteers. The peak value of fermentation as read by hydrogen levels is captured after passage of the orocecal segment in the colon. Comparison are made between IBS patients and healthy subjects as regards orocecal transit time and peak fermentation in the cecum.
Patients with IBS of various kind (constipation-dominant, diarrhea-dominant, and mixed form)
in large numbers are studied as regards orocecal transit time and compared to healthy
controls.
Inclusion criteria: IBS patients 18-80 years old, diagnosis of IBS; exclusion: Severe
cardiac, pulmonary, liver or kidney disease, bloody stool After fasting for 12 hours, all
subjects ingest 10 grams of lactulose. Hydrogen production, measured as hydrogen
concentration in breath, is estimated at 10-minute intervals for a period of 240 minutes. The
orocecal transit transit time is measured from ingestion of the lactulose solution until
hydrogen peaks to 10 and 20 ppm when passing the ileocecal valve, being fermented by the
cecal microflora. Data are compared to those of healthy volunteers.
The peak value of fermentation as read by hydrogen levels (ppm) captured after passage of the
ilecocecal valve orocecal valve signifies the gas production of the micro13flora. Comparison
are made between IBS patients and healthy subjects as regards orocecal transit time and peak
fermentation in the cecum.
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